Figures & data
Figure 1. Relative expression of HOXC6 was determined using qRT-PCR and Western blot analysis. Compared with adjacent non-cancerous tissues, relative expression of HOCX6 was significantly up-regulated in PCa tissues at both mRNA (A) and protein (B) levels (p < .05). Relative expression of HOXC6 was also distinctively higher in cell line LNCaP than in normal human prostate epithelial cells RWPE-1 at both mRNA (C) and protein (D) levels (p < .05).
Table 1. Relationship between HOXC6 expression and clinical characteristics of patients with PCa.
Figure 2. The effects of HOXC6 on the proliferation of PCa cells. (A) The expression of HOXC6 was down-regulated after transfected with si-HOXC6 (p < .05). (B) The down-regulation of HOXC6 suppressed the proliferation of PCa cells (p < .05).
Figure 3. The influences of HOXC6 on the migration and invasion of PCa cells. (A) The down-regulation of HOXC6 inhibited the migration of PCa cells (p < .05). (B) Transwell assay displayed that cells transfected with si-HOXC6 had lower invasion capacity than those transfected with si-NC (p < .05).
Figure 4. Kaplan–Meier analysis was carried out to investigate the relationship of HOXC6 expression with overall survival of PCa patients. The curves showed that patients with low HOXC6 expression lived longer than those with high HOXC6 expression (log rank test, p < .001).
Table 2. Univariate and multivariate analyses adjusting clinical factors to estimate prognostic value of HOXC6 in PCa, using cox regression analysis.