Dosage of sugammadex according to the calculated lean body mass in obese female patients: time to reverse moderate neuromuscular blockade induced by rocuronium

Figures & data

Table 1: Demographic and surgical patient data

Patients	Weight (kg)	Height (cm)	BMI (kg/m^2)	CLBM (kg)	Surgery
1	110	163	41.40	51.20	Gastric bypass
2	119	169	41.66	54.81	Gastric bypass
3	95	154	40.06	44.76	Gastric banding
4	130	176	41.97	58.00	Gastric banding
5	108	160	42.17	48.10	Gastric banding
6	112.5	168	39.86	53.90	Gastric banding
7	108	162	41.15	49.12	Gastric banding
8	107	162	40.77	50.02	Gastric banding
9	95	154	40.06	44.76	Gastric banding
10	124	162	47.25	47.20	Gastric banding
11	111	160	43.36	48.31	Gastric banding
12	130	176	41.97	58.00	Gastric banding
13	90	155	37.46	46.51	Gastric banding
14	109	166	39.56	52.16	Gastric bypass
15	108	159	42.72	47.12	Gastric bypass
16	106	154	44.69	42.96	Gastric banding
17	124	182	37.43	64.24	Gastric banding
18	108	158	43.26	47.13	Sleeve
19	97	161	37.42	50.51	Gastric banding
20	115	161	44.36	48.44	Gastric banding

Figure 1. Time to recover 4 on TOF and ratio T4/T1 90%.

Table 2: Study results

Patients	Anaesthesia time in minutes	Body temperature in C°	Dose of rocuronium in mg	Dose of sugammadex in mg	Time to TOF T4 in seconds and (minutes)	Time to 90% recovery in seconds and (minutes)
1	176	31.6	95	100	30 (0.5)	195 (3.2)
2	186	33.5	85	110	30 (0.5)	225 (3.7)
3	92	36.8	65	90	75 (1.2)	255 (4.2)
4	89	34.0	70	115	45 (0.7)	210 (3.5)
5	97	33.5	60	100	30 (0.5)	60 (1)
6	92	35.7	75	108	30 (0.5)	60 (1)
7	84	34.0	70	100	45 (0.7)	150 (2.5)
8	93	35.7	65	100	45 (0.7)	285 (4.7)
9	92	35.1	65	90	75 (1.2)	150 (2.5)
10	101	34.3	75	95	90 (1.5)	150 (2.5)
11	69	33.3	60	95	95 (1.6)	105 (1.7)
12	142	35.4	95	100	60 (1)	120 (2)
13	83	34.9	62.5	95	45 (0.7)	90 (1.5)
14	188	34.1	78.5	105	15 (0.2)	90 (1.5)
15	241	31.1	95	95	45 (0.7)	285 (4.7)
16	82	33.8	55	90	60 (1)	255 (4.2)
17	109	30.2	85	130	75 (1.2)	195 (3.2)
18	104	34.7	65	95	90 (1.5)	210 (3.5)
19	189	35.2	85	100	75 (1.2)	135 (2.2)
20	60	35.2	50	100	60 (1)	120 (2)

Figure 2: Regression graph between time to recovery 90%, and weight in kg.

Figure 3: Regression graph between time to recovery 90%, and BMI in kg/m².

Figure 4: Regression graph between time to recovery 90%, and CLBM in kg.

Figure 5: Relation between time to recovery 90% and temperature.