The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences: protocol for a dietary intervention study

Figures & data

Figure 1. Study outline: Two 3-day diet intervention periods separated by one 7-day wash-out period. Participants had five visit days (blue). ✓ marks the main days a measurement or sample was taken, i.e. for most participants, and (✓) marks days the measurement/sample was taken, if not possible on the main day. *Dietary interview performed on one of the marked visits. **Oral sucrose tolerance test performed before day −7 for participants recruited by symptoms (unknown genotype).

Table 1. Overview of fasting blood samples collected from each participant. All samples were collected at baseline. * Triglycerides, VLDL-, LDL-, HDL-, total and remnant cholesterol. ** At screening for participants from the open recruitment.

Blood sample for analysis of:	Before intervention 1	After intervention 1	Before intervention 2	After intervention 2
HbA1c	x
Plasma glucose	x
Serum insulin	x	x	x	x
Plasma C-reactive protein	x	x	x	x
Lipids*	x	x	x	x
Plasma lipidomics	x	x	x	x
Plasma metabolomics	x	x	x	x
Plasma proteomics	x	x	x	x
Short chain fatty acids (2 h post ingestion in sucrose tolerance test)	(x)**			x