Autophagy at the postsynapse begins with Rab11 and does not end with dendritic spine pruning

Figures & data

Figure 1. Rab11 participates in autophagosome formation in the dendritic spine (a simplified model). (A). At baseline, Rab11 recycling endosomes supply the postsynaptic site with Atg9A containing endomembranes. (B). When mTOR becomes locally inactive, Rab11 positive endomembranes accumulate with Atg9A positive compartment. (C). Upon NMDAR-driven cLTD, subsequent autophagy-related proteins, including LC3, become recruited to the Rab11-Atg9A compartment and membrane is donated to the newly forming phagophore. Created with BioRender.com.