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Research Article

Unusual D‐Lactic Acid Acidosis from Propylene Glycol Metabolism in Overdose

, M.D., Ph.D., , M.D., , Ph.D., , Ph.D., , M.D., Ph.D., , M.D., Ph.D. & , M.D., Ph.D. show all
Pages 163-169 | Received 25 Mar 2003, Accepted 19 Nov 2003, Published online: 05 Nov 2004
 

Abstract

Objective: To report a case of D‐lactic acid acidosis owing to massive oral ingestion of propylene glycol. Case Report: A 72‐year old man with known congestive failure was admitted to the ICU with encephalopathy. Twelve hours prior to admission he had erroneously ingested a large amount of propylene glycol (PG). The laboratory revealed high anion gap (anion gap = 27 meq/l) acidosis (arterial pH = 7.16) and an increased osmolal gap. Toxicological analysis revealed a low serum propylene glycol level. Biochemical analysis indicated that very high amounts of D‐lactic acid (up to 110 mmol/l), but not of the usual type of L‐lactic acid, were responsible for the metabolic acidosis. Hemodialysis was initiated and associated with a decline of both the acidosis and D‐lactic acid levels. The patient regained conciousness. Conclusion: Ingestion of massive doses of propylene glycol, previously not reported as a cause of D‐lactic acidosis, should be added to the differential diagnosis of this rare condition.

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