NO ASSOCIATION OF GLUTATHIONE S-TRANSFERASE M1 GENE POLYMORPHISM WITH DIABETIC NEPHROPATHY IN JAPANESE TYPE 2 DIABETIC PATIENTS

Figures & data

Figure 1. GSTM1 genotyping. Lane 1: DNA size marker (100-bp DNA Ladder); Lanes 2 and 3: GSTM1 null genotype; Lanes 4 and 5: GSTM1 positive genotype.

Table 1. Clinical Characteristics

	Without nephropathy (n = 69)	With nephropathy (n =105)
Gender (M/F)	32/37	62/43
Age (years)	62 ± 10	60 ± 12
BMI (kg/m^2)	22.8 ± 3.0	22.9 ± 4.9
HbA1c (%)	7.6 ± 2.0	7.8 ± 1.7
Serum creatinine (μmol/L)	62 (44–115)	106 (35–548)^*
Hypertension (n (%))	35 (50.7)	91 (86.7)^*

Data are means ± SD or median (range). BMI, body mass index.

^* p < 0.001.

Table 2. GSTM1 Genotype Frequency

	Without nephropathy (n =69)	With nephropathy (n =105)	p value
Positive	31 (44.9)	54 (51.4)
Null	38 (55.1)	51 (48.6)	p = 0.401

Data are n (%). ‘Positive’ indicates the presence of the GSTM1 gene. ‘Null’ indicates the homozygous deletion of the GSTM1 gene.