URINARY THYMIDINE GLYCOL AS A BIOMARKER FOR OXIDATIVE STRESS AFTER KIDNEY TRANSPLANTATION

Figures & data

Table 1. Profiles of patients with kidney transplantation. Two cold storage solutions were used University of Wisconsin solution (UW) and Eurocollins solution (EC)

Patient (no)	Age (years)	Sex (m/f)	Number of HLA - matches	Duration of cold storage (h)	Duration of anastomosis (min)	Cold storage solution (EC/UW)
1	47	m	6	12	35	EC
2	50	m	6	15.5	35	UW
3	60	m	5	21.5	35	UW
4	51	m	2	22.5	33	UW
5	28	m	6	14.5	35	UW
6	39	m	6	19	38	UW

Table 2. Urinary excretion ratios of proteins (g/mmol creatinine) and of thymidine glycol (nmol/mmol creatinine) in 6 patients up to ten days after kidney transplantation

	Time after reperfusion
	1 h	3 h	7 h	24 h	2 days	4 days	7 days	10 days
Total protein	7.2	3.5	0.82	0.35	0.29	0.12	0.13	0.08
Albumin	5.83	1.2	0.40	0.17	0.09	0.01	0.04	0.02
α1-microglobulin	0.082	0.089	0.048	0.028	0.046	0.020	0.016	0.023
β2-microglobulin	0.015	0.016	0.012	0.010	0.009	0.003	0.005	0.0025
Transferrin	0.49	0.068	0.022	0.0046	0.0045	0.0009	0.0013	0.0015
α2-macroglobulin	0.0101	n.d.	0.0022	0.0011	n.d.^*	n.d.^*	n.d.^*	n.d.^*
IgG	1.24	0.17	0.046	0.017	0.011	0.002	0.0038	0.0009
Thymidine glycol	n.d.	1.65	5.79	10.76	16.56	12.27	8.06	11.45

^*n.d. = not detectable.

Figure 1. Time course of urinary thymidine glycol (TG)/creatinine excretion ratio (mmol/mmol) in 6 patients up to 10 days after renal transplantation (logarithmic scales for x-axis and linear for y-axis; curve fitting was performed using a polynomial function (median ± 95% confidence interval)).

Figure 2. Time course of urinary protein/creatinine excretion ratio (g/mmol) in 6 patients until 10 days after renal transplantation (logarithmic scales for x-axis and y-axis; curve fitting was performed using a polynomial function [median ± 95% confidence interval]).