Invasive aspergillosis in pediatric patients

Figures & data

Table 1.  Risk factors for overall mortality in 139 cases of pediatric invasive aspergillosis.

Characteristic	Survival (n = 66)	Death (n = 73)	p-value
Bone marrow transplant, n (%)			0.001
Autologous	1 (2)	1 (1)
Allogeneic	11 (17)	40 (55)
GVHD, n (%)	3 (5)	20 (27)	0.010
Steroid therapy, n (%)	42 (64)	62 (85)	0.033
Immunosuppression, n (%)	22 (33)	47 (64)	0.001
Surgery post diagnosis, n (%)	38 (58)	23 (32)	0.045

GVHD= graft-versus-host disease.

Adapted from Burgos et al., 200826.

Table 2.  In-hospital mortality rate by underlying condition.

Underlying condition*	Mortality rate, %		RR (95% CI)	p-value
	Patients with IA (N = 666)	Patients without IA (N = 151,537)
Malignancy	21	1	13.5 (10.9−16.8)	<0.001
Solid tumor	18	1	14.0 (6.8−28.6)	<0.001
Leukemia	21	2	11.0 (8.5−14.2)	<0.001
ALL	21	1	14.9 (10.2−21.7)	<0.001
AML	20	3	5.0 (3.3−7.4)	<0.001
Lymphoma	29	2	13.5 (6.7−27.1)	<0.001
Other malignancy (NOS)	19	2	9.5 (5.3−17.0)	<0.001
Hematologic disorder (aplastic anemia)	22	3.4	5.3 (3.7−7.5)	<0.001
Immunodeficiency†	6	2.3	2.4 (1.1−5.2)	0.2
Solid-organ transplant	33	6	4.7 (0.9−23.6)	NA
Bone marrow transplant	44	8	3.8 (2.6−5.6)	<0.001
Allogeneic	45	11	3.3 (2.2−4.8)	<0.001
GVHD	44	10	3.4 (2.2−5.3)	<0.001
Non-GVHD	52	13	3.0 (1.4−6.1)	<0.001
Autologous	66	3	–	NA

*Patients may have presented with >1 condition.

†All immunodeficiency conditions combined.

IA = invasive aspergillosis; RR = relative risk; CI = confidence interval; ALL = acute lymphocytic leukemia; AML = acute myeloid leukemia; NOS = not otherwise specified; NA = not available.

Adapted from Zaoutis et al., 20067.

Burgos A, Zaoutis TE, Dvorak CC, et al. Pediatric invasive aspergillosis: a multicenter retrospective analysis of 139 contemporary cases. Pediatrics 2008;121:e1286-94

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Zaoutis TE, Heydon K, Chu JH, et al. Epidemiology, outcomes, and costs of invasive aspergillosis in immunocompromised children in the United States, 2000. Pediatrics 2006;117:e711-16

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