Figures & data
Figure 1. Conceptual framework. Vision biomarkers determine clinical AMD risk (high or low) whereas genetic risk alone cannot. Each person has a unique exposure to environmental risk factors. For example in the case of a low risk genotype who develops AMD, vision biomarkers would show deterioration over time as environmental risk was higher. In case of a high risk genotype, vision biomarkers show no impairment over time as there is no (less) environmental risk. Thin arrows indicate alternate pathways.
