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Abstract
Background: Owing to worldwide use of asbestos during the past century, the global incidence of mesothelioma is still increasing. Although the outcome for patients remains poor, there has been definite progress in the systemic treatment of this disease within the past 5 years. Objective: By examining the clinical trials performed and the role of novel emerging agents, this review aims to provide an ‘expert opinion’ on evidences that validate chemotherapy as current ‘standard of care’ for inoperable mesothelioma. Methods: Relevant literature about clinical trials was reviewed using a PubMed search and other relevant data about novel therapeutic approaches both established and in development. Conclusion: The response rates achieved using chemotherapeutic treatments are higher than previous ones, and in the future may be improved by the use of combined and personalized therapies.