Figures & data
Figure 1. Interorgan ammonia trafficking. Ammonia derived from gut and kidneys, mainly due to glutaminase activity, must be detoxified in muscles because of possible liver dysfunction. Systemic hyperammonemia promotes brain uptake and induces low-grade cerebral edema, as well as alterations in neurotransmission.
Figure 2. Management of overt hepatic encephalopathy.
Figure 3. Key aspects in the treatment of overt hepatic encephalopathy.
Figure 4. Secondary prophylaxis using rifaximin or lactulose in patients with previous overt hepatic encephalopathy.
