Figures & data
Figure 1. A. Growth and development of biofilms. In the center is seen the microcolony formation seen in biofilms. Lower right demonstrates polymicrobial biofilms formed through specific cell–cell signaling and attraction. Upper right demonstrates the mechanism of biofilm spread where cells become motile, swim away as a planktonic population and following to the left go through a cycle of reversible adherence, tight adherence and microcolony formation again under regulation of specific cell–cell communication. B. Multifactorial mechanisms that contribute to antibiotic tolerance developed within a biofilm.
Table 1. Susceptibility of a Pseudomonas aeruginosa cystic fibrosis isolate as a planktonic and biofilm culture to individual or combinations of antibiotics at breakpoint levels in the bioFILM PA™ Assay.