Bioenergetics failure in neurodegenerative diseases: back to the future

Figures & data

Figure 1. The primary aberrant protein drivers and molecular pathways that may be involved in creating energy deficits in neurons triggering dysfunction and disease in AD, PD and HD.

Table 1. Therapeutic targets.

Disease	Target	Function	Therapy approach
Alzheimer's	Pyruvate dehydrogenase (PDH)	Rate limiting for initiation of Kreb's cycle	Direct activation of PDH or blocking upstream inhibitory kinase
Parkinson's	PGC-1α	Energy generation and mitochondrial biogenesis	PPAR-γ agonism
Huntington's	PGC-1α	Energy generation and mitochondrial biogenesis	PPAR-γ agonism