Figure 1. Schematic representation of the ADAMTS7 protein (see text). The terminal TS motif domain is the site for cartilage oligomeric matrix protein (COMP) and granulin-epithelin precursor (GEP) binding.
Figure 2. Proposed mechanism of ADAMTS7 mediates vascular smooth muscle cell (VSMC) migration. Activated ADAMTS7 cleaves cartilage oligomeric matrix protein (COMP), thereby removing its inhibitory effect on VSMC. Sites of pathway regulation are displayed in red text.
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
To request a reprint or corporate permissions for this article, please click on the relevant link below:
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
Obtain permissions instantly via Rightslink by clicking on the button below:
If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.