Figures & data
Figure 1. Mitochondrial hyperfusion induced by depletion of Drp1 causes genome instability. MDA-MB-231 breast cancer cells stably expressing mitochondria-targeted GFP were transfected with control or Drp1 siRNA for 4 days. DNA was visualized by DAPI staining. Control cells contained the relatively short and dispersed mitochondria. In contrast, Drp1 knockdown cells showed hyperfused mitochondria concomitant with the disorganized nuclear structure and micronuclei, a marker for genome instability.
