Figures & data
Figure 1. Aspirin and major metabolic pathways involved in the generation of biologically active mediators from long-chain polyunsaturated fatty acids: ω-6 AA, ω-3 EPA and ω-3 DHA. Aspirin (ASA) by acetylating (COX1, COX2) blocks COX-dependent generation of proinflammatory prostaglandins and platelet-aggregating thromboxanes; simultaneously, acetylated COX-2 (COX2-ASA) activates new biochemical pathways leading to the formation of AT anti-inflammatory pro-resolving mediators: AA → lipoxins, EPA → E-resolvins, DHA → D-resolvins. For other explanations see text.
