Figures & data
Figure 1. Interrelationship between EMT, cancer stem cells, miRNA and chemoresistance. Significant interrelationship exists between chemoresistance, epithelial to mesenchymal transition and metastasis, which adversely impacts treatment outcomes. Chemoresistance, a key feature of CSCs and cells undergoing EMT, is regulated by the dysregulation of miRNAs. Our proposed combination therapy with PTX and CYA simultaneously targets CSCs and bulk cancer cells, reverses EMT and restores expression of miRNAs altered during generation of chemoresistance and is a viable strategy for treating drug-resistant prostate cancer.
Figure 2. Interrelationship between cancer stem cells (CSCs), miRNA and chemoresistance.
