The potential of calcium silicate hydrate as a carrier of ibuprofen

Figures & data

Figure 1. (A) N₂-adsorption–desorption isotherms and pore size distribution curves of HNMS-CSH and their ibuprofen drug delivery systems (IBU–HNMS-CSHn), where n/100 is the feeding weight ratio of IBU to HNMS-CSH; (B) TG curves of HNMS-CSH and IBU–HNMS-CSHn; (C) IBU-release profiles of the IBU–HNMS-CSHn drug delivery systems in SBF and (D) the cumulative IBU-release percentage versus natural logarithm of release time plots for IBU–HNMS-CSHn drug delivery systems (n = 200, 267 and 400).

Table 1. The experimental results for the IBU–HNMS-CSHn drug delivery systems.

Drug delivery system	Specific surface area (m^2·g^–1)	Pore volume (cm^3·g^–1)	Drug-loading capacity (wt%)	Drug-loading efficiency (%)*
HNMS-CSH	290	1.20	–	–
IBUHNMS-CSH200	30	0.17	172	86.0
IBUHNMS-CSH267	∼ 9	0.04	229	85.8
IBUHNMS-CSH400	∼ 9	0.04	190	47.5

*Drug-loading efficiency = the weight of loaded IBU in the carrier/the initial IBU weight in solution × 100%.

CSH: Calcium silicate hydrate; HNMS-CSH: Nanostructured CSH mesoporous microspheres; IBU: Ibuprofen.

Figure 2. Comparison of drug-loaded CSH and CS nanocarriers with calcium acetate monohydrate; (A) Ca K-edge XANES total electron yield of CSH and CS nanocarriers with IBU; and (B) first derivative of CSH mesoporous microspheres XANES before and after IBU loading.

Wu J, Zhu YJ, Cao SW, Chen F. Hierarchically nanostructured mesoporous spheres of calcium silicate hydrate: surfactant-free sonochemical synthesis and drug-delivery system with ultrahigh drug-loading capacity. Adv Mater 2010;22:749-53

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Guo XX, Wu J, Yiu YM, et al. Drug–nanocarrier interaction—tracking the local structure of calcium silicate upon ibuprofen loading with X-ray absorption near edge structure (XANES). Phys Chem Chem Phys 2013;15:15033-40

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