T cells produce both Th2 cytokines, which promote eosinophilia, and IFN-g, which is involved in granuloma formation. Vascular damage may depend on T-cells, ANCA- or eosinophil-mediated cytotoxicity. ANCA: Antineutrophil cytoplasmic antibodies; DC: Dendritic cell; HMGB: High mobility group-1 protein; MPO: Myeloperoxidase; TEFF: T-cell terminally differentiated; TEM: T cell effector memory; TRAIL: Tumor necrosis factor-related apoptosis-inducing ligand.
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