Tissue adhesives in ocular surgery

Figures & data

Figure 1. Sutureless sealing of a full-thickness stellate corneal laceration.

(A) Full-thickness stellate corneal laceration. (B) Sealed with cyanoacrylate glue without sutures.

Figure 2. Pterygium excision with conjunctival autograft attached with fibrin glue.

(A) Before operation; (B) 1 day after operation; (C) 1 week after operation; (D) 3 months after operation.

Figure 3. Illustration of cohesion interactions between molecules within the tissue adhesive, and adhesion interactions between molecules at the tissue adhesive and the tissue surfaces.

Figure 4. Visualization of transglutaminase activity in human cornea.

(A) Endogenous transglutaminase (TGase) incorporates biotinylated cadaverine in the presence of calcium at pH 7.4 into the tissue. Made visible using streptavidin-dichlorotriazinylaminofluorescein (green fluorescence), the epithelial activity can be attributed to TGase-1 and -3, while the stromal activity can be assigned to TGase-2. (B) Exogenously added TGase-2 crosslinks the tagged peptide into all the layers of the cornea with preference for the stroma, indicating the presence of abundant enzyme substrate sites for this enzyme here. (A´) and (B´): Calcium chelation with ethylene glycol tetra-acetic acid abolishes enzymatic activity.

Activity Evaluation: Where 1 is strongly disagree and 5 is strongly agree

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1. The activity supported the learning objectives.
2. The material was organized clearly for learning to occur.
3. The content learned from this activity will impact my practice.
4. The activity was presented objectively and free of commercial bias.