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Expert Review of Anti-infective Therapy Volume 8, 2010 - Issue 4
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Editorial

Problems and hopes in the development of drugs targeting the fungal cell wall

Vishukumar Aimanianda Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris cedex 15, France
&
Jean-Paul Latgé Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris cedex 15, France. [email protected]
Pages 359-364 | Published online: 10 Jan 2014

Figures & data

Figure 1. Functions of the fungal cell wall.
Figure 1. Functions of the fungal cell wall.
Figure 2. Composition of the fungal cell wall.

Adapted from Citation[1].

Figure 2. Composition of the fungal cell wall.Adapted from Citation[1].
Figure 3. Number of genes per family of carbohydrate active enzymes in the Aspergillus fumigatus cell wall.

Arrows indicate that one gene has been shown to be essential in the family.

AGS: α-1,3-glucanosyltransferase; Chi: Endo-chitinases; CHS: Chitin synthase; CRH: Glucan-chitin transferase; FKS: β-1,3-glucan synthase; GEL: β-1,3-glucanosyltransferase; Glu: Endo-β-1,3-glucanase; PMT: O-mannosyltransferase.

Figure 3. Number of genes per family of carbohydrate active enzymes in the Aspergillus fumigatus cell wall.Arrows indicate that one gene has been shown to be essential in the family.AGS: α-1,3-glucanosyltransferase; Chi: Endo-chitinases; CHS: Chitin synthase; CRH: Glucan-chitin transferase; FKS: β-1,3-glucan synthase; GEL: β-1,3-glucanosyltransferase; Glu: Endo-β-1,3-glucanase; PMT: O-mannosyltransferase.
Figure 4. Essential sequential steps in the construction of the cell wall polysaccharide skeleton.

UDP: Uridine diphosphate.

Figure 4. Essential sequential steps in the construction of the cell wall polysaccharide skeleton.UDP: Uridine diphosphate.

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