Induction of anti-tumor immunity and T-cell responses using nanodelivery systems engrafting TLR-5 ligand

Abstract

Evaluation of: Faham A, Altin JG. Antigen-containing liposomes engrafted with flagellin-related peptides are effective vaccines that can induce potent antitumor immunity and immunotherapeutic effect. J. Immunol. 185(3), 1744–1754 (2010).

Induction of activated T-cell responses is a prerequisite for the development of vaccine against intracellular infection and for the control of cancer. Particulate nanoscale delivery systems deliver antigens intracellularly and help in inducing T-cell responses. T-cell responses can be further augmented by targeting these particles to dendritic cells, which have the ability to induce both innate and adaptive immune responses. Flagellin, which acts as a TLR-5 ligand, has been extensively explored for its adjuvant activity. The paper under evaluation reports a novel vaccine delivery platform technology for induction of a T-cell response using a nanoscale liposome containing antigen and a small synthetic peptide representing TLR-5-binding motifs of flagellin. Vaccination using this nanodelivery system activated dendritic cells through TLR-5 activation and induced both innate and adaptive immune responses. Such novel delivery systems can improve modern vaccine formulation, particularly for the generation of activated T-cell responses and anti-tumor immunity.

Keywords::

• anti-tumor immunity
• dendritic cells
• flagellin
• liposome
• T-cell response
• vaccine

Financial & competing interests disclosure

The author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.