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Future Science OA Volume 9, 2023 - Issue 9
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Review

The Impact of Cellular Environment on In Vitro Drug Screening

Aiman Moldasheva1 Department of Biomedical Science, Nazarbayev University School of Medicine, Astana, 010000, Kazakhstan
,
Laura Bakyt1 Department of Biomedical Science, Nazarbayev University School of Medicine, Astana, 010000, Kazakhstan
,
Denis Bulanin1 Department of Biomedical Science, Nazarbayev University School of Medicine, Astana, 010000, Kazakhstan
&
Mohamad Aljofan1 Department of Biomedical Science, Nazarbayev University School of Medicine, Astana, 010000, Kazakhstan;2 Drug Discovery & Development Laboratory, Centre of Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, 010000, KazakhstanCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-3205-3388
ORCID Icon
Article: FSO900 | Received 22 Feb 2023, Accepted 17 Aug 2023, Published online: 07 Sep 2023

Figures & data

Figure 1. Increased glucose level is associated with increased expression of EGF, TNF-α, IL-6, COX-2 and transition of epithelial cells to mesencymal cells – all of which can contribute to increased cellular proliferation and decreased apoptosis.
Figure 1. Increased glucose level is associated with increased expression of EGF, TNF-α, IL-6, COX-2 and transition of epithelial cells to mesencymal cells – all of which can contribute to increased cellular proliferation and decreased apoptosis.
Figure 2. pH reversal in cancer cells compared with normal cells.

In normal cells intracellular environment is usually more acidic compared with the extracellular, whereas cancer cells have more acidic extracellular environment compared with intracellular.

Figure 2. pH reversal in cancer cells compared with normal cells.In normal cells intracellular environment is usually more acidic compared with the extracellular, whereas cancer cells have more acidic extracellular environment compared with intracellular.

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