Psychological consequences of childhood obesity: psychiatric comorbidity and prevention

Figures & data

Table 1 Global incidence of overweight and obesity in childhood

• Of the 42 million overweight children worldwide, ~31 million live in developing countries^Citation1

• In the United States, childhood obesity incidence has more than doubled in children and quadrupled in adolescents in the past 30 years. One-third of the US children/adolescents in the general population are currently overweight/obese^Citation86,Citation87

• Overweight/obesity in children aged 11–13 years across 36 countries in WHO European region ranges from 5% to >25%^Citation88

• Australia, with the sixth highest prevalence of the population being overweight or obese among OECD countries^Citation89, has ~25% of overweight children aged 2–16 years with 6% being classified as obese^Citation2,Citation90

• In the last 25 years, the number of overweight or obese children living in the African continent has surged from 5.4 million to 10.3 million. This means 25% of all overweight or obese preschool age children live in the WHO African regions^Citation1

Abbreviations: OECD, Organization for Economic Cooperation and Development; WHO, World Health Organization.

Table 2 Complete list of search terms

(childhood obesity or pediatric obesity or obese children or obese child) and (comorbidity or comorbidities or co-morbidity or co-morbidities) and (identification or diagnosis) and (prevention or treatment or treatments or therapy or therapies or intervention or interventions) and (psychiatric or psychological or cognitherapy or cognitive behavio?r therapy or motivational enhancement or antipsychotics or body image or body image disturbance or body dissatisfaction or body shape discontent or self-esteem or depression or anxiety or disordered eating or weight stigmatization or weight bias or bullying or stress or cognitive impairment or attention-deficit disorder or low health-related quality of life or self-perception or long-term effects or school performance)

Figure 1 PRISMA flow diagram of search results.

Abbreviation: PRISMA, Preferred Reporting Items for Systematic Reviews and Meta-Analyses.

Table 3 Summary of depression and anxiety papers (by authors in alphabetical order) (n=16)

Authors	Year	Study design	Age (years)	n	Population	Key measures	Main findings
Anderson et al^Citation4	2006	Prospective longitudinal 4 Waves between 1975 and 2003	Wave1: 9–18 Wave2: 11–22 Wave3: 17–28 Wave4: 28–40	776 775 776 661	Community-based, US	BMI z-scores (age-sex centiles-CDCAP). DSM-III children/DSM-IV: anxiety/depressive disorders	Anxiety/depression were only associated with higher BMI z-scores in females
Anderson et al^Citation18	2007	Prospective longitudinal 1983, 1985, 2003	12–17.99	701	Community-based, US	BMI-OB (age-sex centiles-CDCAP) Diagnostic interview: MDD/anxiety disorder	Females OB as adolescents possible at increased risk for depression or anxiety disorders
Anton et al^Citation19	2006	Cross-sectional	11–13	45	Sixth-grade students, US	BMI OB (age–sex centiles–CDCAP) Behavioral measures SAPAC (activity/sedentary) CDI – depressed mood levels ChEAT – maladaptive eating attitudes	Specific aspects of depression (ie, interpersonal problems/feelings of ineffectiveness) positively correlated with increased sedentary activity
Bell et al^Citation16	2011	Cross-sectional	6–13	283	GAD (Growth and Development Study)	BMI z-scores (age–sex centiles–CDCAP) Structured medical interview: psychosocial symptoms, depression, anxiety + bullying	Increased psychological symptoms reported in OW/OB individuals Increased teasing/bullying
Bell et al^Citation15	2007	Cross-sectional Part of prospective “Growth and Development” (GAD) study	6–13	177 n=73 n=53 n=51	OW/OB children seeking treatment Weight: Normal/OW/OW seeking treatment	BMI z-scores (age–sex centiles–CDCAP) Structured medical interview: psychosocial symptoms, depression, anxiety + bullying	Increased depression with increased BMI z-score Proportion of children reporting bullying/teasing significantly increased with increasing BMI z-scores
Bjornelv et al^Citation20	2011	Population-longitudinal	13–18	8,090	Young-HUNT-1	BMI (international age/sex specific cutoffs) Physical/mental health questionnaire – eating problems, self-esteem, personality, anxiety/depression	No sex differences: in psychological factors/weight problems Low self-esteem with OW/OB but no reports of anxiety/depression/emotional or personality traits
Eschenbeck et al^Citation17	2009	Community-based	6–14	156,948	German national health insurance data	ICD-10: physician diagnosis of OB/psychiatric disorders (ie, external, eg, ADHD, conduct issues; internal, eg, depression/anxiety)	OB significantly associated external and internal disorders Increased OR higher in OB girls for both external and internal disorders No gender differences in OB/conduct Older OB children (12–14 years) increased OR of internal disorders
Gibson et al^Citation21	2008	Cross-sectional	8–13	262	Population-based: Children: healthy weight (n= 158) OW (n=77) OB (n=27)	BMIz-scores, (age–sex centiles–CDCAP) 118 self-report questionnaire: depression, QoL, self-esteem, body dissatisfaction, eating disorder, peer relationships, behavioral/emotional problems	Increased BMI z-score associated with increasing levels of psychosocial distress significantly correlated with depression Interaction between increased BMI z-score and gender - girls having a significantly stronger increase in depression than boys
Goldstein et al^Citation11	2008	Clinical-cohort	7–17	348	Diagnosed (bipolar disorder, BP), US	BMI (IOTF criteria). K-SADS-PL interview (child/parent) – comorbid diagnoses (eg, anxiety, conduct), clinical characteristics (eg, psychoses), mood symptoms/suicide tendencies SES	OW/OB adolescents with BP: Prevalence modestly greater than general population May be associated with increased psychiatric burden
Hoare et al^Citation22	2014	Cross-sectional	11–14	800	Schoolchildren, Australia	BMI (WHO criteria). Behaviors: ABAKQ for activity levels and diet. (PA measured against Australian Govt PA guidelines for adolescents; Diet using WHO guidelines-daily intake) SMFQ-D-Depressive symptomology/anxiety/behavior using SMFQ-D (high internal consistency).	Higher odds of depressive symptoms in OW/OB males before/after adjusting for covariates (than normal-weight adolescents) PA did not show any association with OW/OB
Koch et al^Citation23	2008	Cross-sectional/longitudinal	1 (n=11,082) 2–3 (n=8,805) 5–6 (n=7,443)	n=5,221 (at all age-points)	Swedish families All babies in Southeast Sweden project (ABIS)	BMI: obese/non-obese (IOTF criteria). Psychological-stress domains (family report): SPSQ.	Children reporting stress (≥2 domains) have significantly higher OR for OB (cross-sectional and longitudinal) Psychological stress (in family) possible contributing factor for childhood OB
Marks et al^Citation5	2009	Retrospective medical record review	4–21	230 Weight only for 121	Individuals (psychiatric consultation), US	BMI (CNRC guidelines). Major psychiatric diagnosis recorded: BP, ADHD, Depression	OW/OB children: No statistically significant difference in rates of most common psychiatric disorders (ie, ADHD, BP disorder/depression) Rates of depression/BP disorder higher than normal/UW children Trend to increasing rates of conduct disorders
Phillips et al^Citation24	2012	Cohort	6–17	249	OB youths treatment clinic, US	BMI (age-sex centiles-CDCAP). Self-report questionnaire (children/parents): CDI PedQoL SAS	Extremely OB youth – higher rates across all psychosocial variables with poorer QoL OB girls scored worse than OB boys only on social anxiety (SAS)
Roth et al^Citation12	2008	Family-based behavioral/treatment	8–12	59	Clinical referral OB mother + children, Switzerland	BMI (IOTF criteria) SES Mental disorders: Mothers – Assessment of mental disorders – DSM-IV/BAI DSM-IV disorders in children (parent/child) Maternal BED – assessed DSM-IV EDE/BAI/BDI (by mother) Child completed: CDI, STAIc for children CBCL	OB children (clinical sample): Higher rate of mental disorder compared with nonclinical Significant higher risk of internalizing problems (depression/anxiety) if mother had mental health disorders Mothers (BED) – children with increased probability of mental disorder Maternal anxiety/depression associated with child’s anxiety/depression Maternal BAI, child's total competence via CBCL were significant predictors of child well-being
Sanderson et al^Citation13	2011	Cohort: 1985+20years	7–15 26–36	2,243	National Australian School survey	BMI z-scores (age/sex specific ≥85th centile; OB ≥30) Diagnosed mental disorders-—DSM-IV	OW/OB in childhood associated with increased risk of diagnosed mood disorder (adulthood, OW girls becoming OB women)
van Wijnen et al^Citation25	2010	Population-based	13–14/15–16	21,730	Dutch Schoolchildren	BMI (self-reported only)– (IOTF criteria) Internet questionnaire: MHI-5	OB boys/girls more likely to be psychologically unhealthy/reported more suicide attempts/thoughts Moderately OW/UW girls more likely to report suicide thoughts/attempts but to a lesser extent than OB adolescents

Note: Refer to Table 6 for abbreviations and outcome measures.

Table 5 Summary of papers included in the review related to self-esteem, HRQoL, conduct, stigmatization, and eating disorders (by authors in alphabetical order) (n = 30)

Authors	Year	Study design	Age (years)	n	Population	Key measures	Main findings
*Bell et al^Citation16	2011	Cross-sectional	6–13	283	Growth and Development (GAD) Study	BMI, z-score (age-sex centiles, CDCAP) Structured medical interview: psychosocial symptoms, depression, anxiety + bullying	OW/OB individuals: Increased psychological symptoms reported Increased teasing/bullying
*Bell et al^Citation15	2007	Cross-sectional Part of prospective GAD study	6–13	177 n=73 n=53 n=51	OW/OB children seeking-treatment Weight: Normal/OW/OW seeking treatment	BMI, z-score (age-sex centiles, CDCAP) Structured medical interview: psychosocial symptoms, depression, anxiety + bullying	Increasing BMI, z-scores: Increased depression Proportion of children reporting bullying/teasing significantly increased
*Bjornelv et al^Citation20	2011	Population, longitudinal	13–18	8,090	Young-HUNT-1	BMI (international age/sex-specific cutoffs) Physical/mental health questionnaire: eating problems, self-esteem, personality, anxiety/depression	No sex differences: in psychological factors/weight problems Low self-esteem with OW/OB but no reports of anxiety/depression/emotional or personality traits
Bolton et al^Citation55	2014	Cohort	11–19.6	1,583	Schoolchildren, Victoria, Australia	BMI (WHO reference data) Self-reported: AQoL-6D	Lower HRQoL: Females compared to males Older compared to younger adolescents OW females compared to healthy-weight females
*Duarte et al^Citation31	2010	Prospective/population-based (national) Recruited –R Assessed – A	R: 8 A: 18–23	2,209	Military examination records, boys, Finland	BMI (military records). Child mental health (8 years) assessed through 3 sources: parents, teachers, and children Parent-teacher: psychopathy using Rutter scale for: conduct, hyperkinetic (related to hyperactivity, inattentive behavior, etc) and emotional domains CDI (self-report): depression	Childhood conduct problems (disobedience/defiance/aggression/cruelty to others/stealing/lying/and destruction of property) prospectively associated with OW/OB young adults
*Eschenbeck et al^Citation17	2009	Community-based	6–14	156,948	German national health insurance data	ICD-10: physician diagnosis of OB/psychiatric disorders (ie, external, eg, ADHD, conduct issues; internal, eg, depression/anxiety)	OB significantly associated external and internal disorders Increased OR higher in OB girls for both external and internal disorders No gender differences in OB/conduct Older OB children (12–14 years) increased OR of internal disorders
Franklin et al^Citation49	2006	Cross-sectional	9–13	2,749	Schoolchildren (Australia)	Height/weight (BMI) Self-perception profile for children: Measure of body shape perception	OW/OB children reported significantly poorer physical appearance, global self-worth
Gerke et al^Citation56	2013	Cohort	11–17	92	OB African-Americans seeking treatment (TEENS) Criteria: ≥95th BMI percentiles for age/sex	Personal/family information: POTS–teasing DHMS–daily hassles Coopersmith SEI, self-esteem CDI-depression ChEDE-Q, eating disorders	Daily hassles, teasing, upset about teasing, depressive symptoms and self-esteem were all significantly correlated with eating pathology
*Gibson et al^Citation21	2008	Cross-sectional	8–13	262	Population-based: children: healthy weight (n=158) OW (n=77) OB (n=27)	BMI (z-scores), (age-sex centiles, CDCAP). 118 self-report questionnaire: depression, QoL, self-esteem, body dissatisfaction, eating disorder, peer relationships, behavioral/emotional problems	Increase BMI z-score associated with increasing levels of psychosocial distress significantly correlated with depression Interaction between increased BMI z-score; and sex: girls having a significantly stronger increase in depression than boys
Guerdijkova et al^Citation64	2007	Medical documentary analysis	<18	44 obese children	Child/adult weight-management program, US 113 including 69 OB adults	BMI (NIH guidelines), weight history Diagnosis using SCI for DSM-IV Axis I Disorders CGI MDQ BDI	Irrespective of age, very high prevalence rates of mood disorders Significantly higher lifetime prevalence of bulimia nervosa in weight-loss seeking patients with childhood OB onset compared with adult-onset OB
Halfon et al^Citation50	2013	Cross-sectional National survey	10–17	41,976–43,297	Population-based, US	BMI (%age/sex 85^th to <95^th; ≥95^th percentiles) Parent report Comorbid health issues (physical/psychological), Behavioral problem Index – ADHD, conduct issues (including school-related)	OW/OB associated with poorer health status, lower emotional functioning, and school-related problems Greater weight associated with higher rates of ADHD, conduct disorders OB children with ADHD strong association (not taking stimulant medications) No associations for children taking stimulants Childhood OW with risk factors for development of psychosocial problems, including weight-based teasing, social stigmatization/peer rejection
Jansen et al^Citation51	2013	Cross-sectional Longitudinal	Wave1: 4–5 Wave2: 10–1 1	3,898	Australian children	BMI (IOTF cutoff points) PedQol Covariates, SAS, age	High BMI, related to poorer HRQoL in late childhood Unique findings, this emerges in 6–7 years
Johnston et al^Citation57	2011	Clinical evaluation trial	6–18	48	Treatment-seeking cohort: OB children, 10-week weight loss program + parent/s, US	BMI (age-sex centiles, CDCAP) Parental report Comorbidity psychiatric conditions: Attention deficit hyperactivity disorders, anxiety, depression and conduct disorder.	Overall, significant reduction in BMI z-score: especially severely obese and children with comorbidity
*Khalife et al^Citation32	2014	Prospective/postal/questionnaire	7–8 16	8,106 6,934	1986 birth-cohort, Finland	BMI (OB defined, IOTF cutoff points) Age 7–8: ADHD/CD symptoms (teacher)/Normal Behavior Scale, BMI/PA (parents) Age 16: ADHD symptoms (parents/SWAN)/PA index of binge eating (self)	Children with ADHD/CD symptoms, increased risk of OB and physically inactive adolescents PA may be beneficial for behavior problems/OB High comorbidity between inattention hyperactivity/CD symptoms Variables significantly associated over time until 16 years, for BMI/inattention symptoms 16 years, slight negative association between BMI/PA BMI/eating-related
Lebow et al^Citation65	2015	Retrospective-cohort Medical record analysis	10–20	179	OW/OB treatment-seeking adolescents (diagnosed restrictive-eating disorders)	BMI (age-sex centiles, CDCAP). Clinical history (patient + parent) EDE-Q.	36% adolescents (for treatment for a restrictive-eating disorder) had weight history >85th BMI percentile
Madowitz et al^Citation58	2012	Cohort	8–12	79	Obese parent–child pairs referred to family-based treatment	BMI UWCBs: weight-related teasing, especially by other children Psychosocial measures	OB children: Teased by other children having significantly higher levels of depression Are five times more likely to engage in UWCBs Children bothered by peer teasing by peers had significantly higher levels of depression Frequency of weight-related teasing significantly associated with depression Number of teasing sources (significantly associated with depression) No significant relationships between familial teasing/depression or UWCBs
^Marks et al^Citation5	2009	Retrospective medical record – review	4–21	230 Weight only for 121	Individuals (psychiatric consultation), US	BMI (CNRC guidelines). Major psychiatric diagnosis recorded: BP, ADHD, depression	OW/OB children: No statistically significant difference in rates of most common psychiatric disorders (ie, ADHD, BP disorder/depression) Rates of depression/BP disorder higher than normal/UW children Trend to increasing rates of conduct disorders
Neumark-Sztainer et al^Citation46	2007	Longitudinal, survey	Mean age:-12.8 (T1: 1999), 17.2 (T2: 2004)	2,516	Adolescents (project EAT)	Weight status: (guidelines for cutoff criteria) Socio-environmental Body image/weight concerns Psychological well-being Depressive symptoms nutritional knowledge/attitudes Behavioral factors Weight-control practices	Weight-specific socio-environmental, personal, and behavioral variables are strong and consistent predictors of OW status, binge eating/extreme weight-control behaviors in adolescence
*Phillips et al^Citation24	2012	Cohort	6–17	249	OB youths, treatment clinic, US	BMI (age–sex centiles–CDCAP) Self-report questionnaire (children/parents): CDI PedQoL SAS	Extremely OB youth, higher rates across all psychosocial variables with poorer QoL OB girls scored worse than OB boys only on social anxiety (SAS)
Quinlan et al^Citation59	2009	Cohort study	12–18	96	Longitudinal weight loss program over summer camp, US	BMI (national cutoff criteria) Self-esteem: Rosenberg Scale Body esteem: body esteem scale Depression: centre for epidemiological studies depressions scale Antifat attitude Feelings/concerns Perceptions of teasing scale Participation/social involvement,camp staff Body concern	More frequent and upsetting weight-related teasing experiences associated with worse psychological functioning Adolescents most distressed by weight-related teasing exhibited lower self-esteem and higher depressive symptoms Competence-related teasing associated with more worries about weight, greater depressive symptoms, and more negative anti-fat attitudes Weight-related teasing associated with lower levels of social involvement for heavier adolescents
Sawyer et al^Citation60	2011	Cohort	4–5 8–9	3,363	Longitudinal study of Australian children	BMI (IOTF cutoff points) Mental health: SDQ completed by parents/teachers PedQoL	>BMI in 4–5 years higher – likelihood of peer problems/teacher reports of emotional issues (8–9 years)
Sawyer et al^Citation52	2006	Cross-sectional	4–5	4,983	Longitudinal study of Australian children Random assignment	BMI (IOTF cutoff points) Mental health	OB children had more peer/conduct problems
Taner et al^Citation53	2009	Cross-sectional	7–16	54	Obese children, Turkey	Diagnosed OB Psychiatric disorders: DSM-IV-TR Clinical interview, K-SADS-PL	50% children/adolescents had comorbid psychiatric disorders Depression/sociophobia, two most common reported
Taylor et al^Citation54	2012	Cross-sectional	7–11	158	Primary children, Australia (and primary caregiver)	BMI (IOTF cutoff points) Child: Authoritative Parenting Index Self-esteem (self descriptive) Child body image Parent covariates, body dissatisfaction and depression	Increasing BMI negatively associated with self-esteem Child weight associated with negative psychological outcomes in young, non-treatment-seeking children Larger BMI negatively associated with child self-esteem and positively associated with child body dissatisfaction Parental responsiveness positively associated with child self-esteem Parenting not associated with child body dissatisfaction Higher child BMI associated with higher body dissatisfaction and lower self-esteem in a young, non-treatment-seeking sample
Wake et al^Citation48	2013	Cross-sectional/longitudinal	2–3 4–5 6–7 8–12 13–18	4,606 4,983 4,464 1,541 928	Two Australian populations HOYVS 2000–2006	BMI (IOTF cutoff points) Parent/self-report: psychosocial/mental health Special health care needs	Normal weight deviations associated with health differences (vary by morbidity/age) Promoting normal weight is central to improving health/well-being of young and with later-life lower risk for disease
Wake et al^Citation47	2010	Cross-sectional School-based/longitudinal	8.4–15.8	923/parents	HOYVS (1997, 2000, 2005): n=24	BMI (IOTF cutoff points) SDQ PedQoL Parent/self-report: psychosocial/mental health Special health care needs	OW/OB adolescents more likely to have poorer health/but not more likely to report specific health issues Morbidity mainly associated with concurrent rather than earlier OW/OB
Walders-Abramson et al^Citation61	2013	Cohort	11–18	166	OB adolescents ≥95th percentile for age/sex (+1 or more metabolic syndrome), endocrinology clinic, US	BMI percentiles (using 99th percentile, extreme/morbid OB) SDQ	Meet criteria for extreme OB alone were more predictive of psychological difficulties Degree of OB more relevant than number of associated comorbidities (psychological health)
Wille et al^Citation62	2010	Multicentre, clinical	8–16	1,916	OW/OB children seeking treatment (patients) (Germany)	BMI (national standards, Germany age/sex-specific >90th percentile or >97th). Demographics HRQoL KIDSCREEN-27 KIDSCREEN-52 KINDL	Presence of differences in HRQoL regarding sex, age, treatment modality, and treatment-seeking OW/OB patients Marked reduction in HRQoL, eg, impaired self-perception/physical well-being No change in KIDSCREEN-27 peer-dimension reports
Zeller et al^Citation66	2006	Retrospective analysis, clinical data	10–18	33	Extremely morbidly obese (seeking treatment/bariatric surgery)	Child: PedQoL, HRQoL BDI Mother: PedQoL-parent-proxy CDI checklist	Daily life for extreme OB adolescents (seeking treatment) is globally and severely impaired Some of these extreme OB adolescents demonstrated clinically significant levels of depressive symptomatology
Zeller & Modi 2006^Citation63	2006	Clinical cohort Mean =12.7	8–18	166 obese youth	70% females, 57% African-American pediatric weight management program	BMI (≥95th percentile) SES PedQoL-HRQoL (Parent-proxy). Youth completed: CDI PedQoL Perceived Social Support Scale for Children	HRQoL scores impaired relative to published norms on healthy youth (P<0.001) ~11% met criteria for clinically significant depressive symptoms Strong predictors of HRQoL included: Depressive symptoms, perceived social support from classmates, degree of OW and SES

Notes: Refer to Table 6 for abbreviations and outcome measures.

* Also cited in Table 3.

^ Also cited in Tables 3 and 4.

Table 6 List of abbreviations and outcome measures cited in Tables 3–5

ABAKQ	Adolescent Behaviours, Attitudes, and Knowledge Questionnaire
ADHD	Attention-Deficit/Hyperactivity Disorder
AQoL-6D	Assessment of Quality of Life-6D scale
BAI	Becks Anxiety Inventory Scale (validated tool)
BDI	Becks Depression Inventory Scale (validated tool)
BED	Binge eating disorder
BMI	Body mass index: weight/height
BMI-SDS	BMI Standard Deviation Score
BP	Bipolar (mental health disorder)
CBCL	Child Behavior Checklist (validated tool)
CBCL-23	Child Behavior Checklist 23 items
CDCAP	Centre for Disease Control and Prevention. Using BMI centiles for age/sex-specific reference
CDI	Child Depression Inventory (validated tool)
CD	Conduct disorders
CDI	Children’s Depressive Symptoms Inventory (validated tool)
CES-DC	Center for Epidemiological Studies Depression Scale for Children
CGI	Clinical Global Impression (severity of mood and eating disorders)
ChEAT	The Children’s Eating Attitudes Test
ChEDE-Q	Children’s Eating Disorder Examination Questionnaire
CNRC	Children’s Nutrition Research Center, US
CPRS	Connors Parenting Rating Scale
CPTRS	Connors Parent and Teacher Rating Scale
DHMS	Daily Hassle Microsystem Scale
DI	Diagnostic Interview
DISC–IV	Diagnostic Interview Schedule for Children
DISC–V1	Diagnostic Interview Schedule for Children 6th Edition
DSM-III	Diagnostic and Statistical Manual of Mental Disorders – 3rd Edition
DSM-IV	Diagnostic and Statistical Manual of Mental Disorders – 4th Edition
DSM-IV-TR	Diagnostic and Statistical Manual of Mental Disorders – 4th Edition, text revision
DSMMD	Diagnostic and Statistical Manual of Mental Disorders
EAT	Eating Amongst Teens
EDE	Eating Disorder Examination
EDE-Q	Eating Disorder Examination Self-Report Questionnaire
EF	Executive Functioning
HOYVS	Health of Young Victorians’ Study
HRQoL	Health-Related Quality of Life
ICD-10	ICD-10 is the 10th revision of the International Statistical Classification of Diseases and Related Health Problems by WHO
IOTF	International Obesity Task force (reference data with cutoff points for weight status)
K-SADS-PL	Schedule for Affective Disorders and Schizophrenia for School-age Children: present and lifetime version (validated tool)
KIDSCREEN-27	Generic HRQoL for youths aged 8–18 years: subscales physical well-being, psychological well-being, autonomy and parents, social support and peers, school environment (validated tool)
KIDSCREEN-52	Self-perception of security and satisfaction, eg, appearance (internal consistency)
KINDL	Measure HRQoL for children and adolescents – captures experiences associated with OW/OB children
MDD	Major depressive disorder
MDQ	Mood Disorder Questionnaire
MHI-5	Mental Health Inventory-5 (validated tool).
MI	Malaise Inventory
NGRCCA	National Growth Reference for Chinese Children and Adolescents
NIH	National Institute of Health
OB	Obese
ODD	Oppositional Defiant Disorder
OR	Odds ratio
OW	Overweight
PA	Physical activity
PedQol	Pediatric Quality of Life inventory (validated tool)
POTS	Perceptions of Teasing Scale (validated tool)
QoL	Quality of life
RPS	Rutter Parent Scale
SAPAC	Self-Administered Physical Activity Checklist (validated tool)
SAS	Social Anxiety Scale (validated tool)
SCID	Structured Clinical Examination for DSM-IV (validated)
SDC	Social Development Scale
SDQ	Strengths and Difficulties Questionnaire (validated tool)
SECCYD	Study of Early Child Care and Youth Development
SEI	Self-Esteem Inventory (validated tool)
SES	Socio-Economic Status
SLAITS	State and Local Area Telephone Survey
SMFQ-D	Short Moods and Feelings Questionnaire (high internal consistency)
SPSQ	Swedish Parenting Stress Questionnaire (4 domains-SPSQ: life-events/social support, frequency of exposure [validated tool])
STAI/STAIc	State Trait Anxiety Inventory/for Children (validated tool)
SWAN	Strengths/Weaknesses of ADHD/Normal Behavior
SPSQ	Swedish Parenting Stress Questionnaire (validated tool)
TEENS	Teaching, Encouragement, Exercise, Nutrition, Support Program
UW	Underweight
UWCBs	Unhealthy Weight Control Behaviors
WHO	World Health Organization

Table 4 Summary of ADHD papers included in the review (by authors in alphabetical order) (n= 17)

Authors	Year	Study design	Age (years)	n	Population	Key measures	Main findings
Anderson et al^Citation30	2010	Longitudinal	2–12	1,237	Child/youth development (SECCYD)	BMI (age–sex centiles–CDCAP) CBCL-23: externalizing behaviors (emotional/behavioral difficulties)	Externalizing behaviors problems associated with higher BMI and OB (as young as 24 months) Behaviors associated (modest effect) in early childhood with weight/status in elementary school years
Anderson et al^Citation29	2006	Prospective/longitudinal 1983 – T1 1985/6 – T2	T1 : ~9–16 T2: ~11–20	655	General population (childhood-adulthood)	BMI z-scores (age–sex centiles–CDCAP) Diagnosis DISC-IV for children for ADHD, defiant disorder/conduct disorder	Subjects with ADHD have higher mean BMI z-scores (all ages) compared with subjects with no disruptive disorder Disruptive disorders associated with elevated weight-status (childhood into adulthood) Possible associations between behavior disorders and increased weight begin early in childhood - possible lifelong health effects
Byrd et al^Citation38	2013	Survey (cohort: 2001–2004)	8–15	3,050	US children	BMI (≥percentile of US reference) ADHD status defined from Dl (DISC-V1) parent report Medication classification: ADHD medication/ADHD unmedicated	Males (medication) had lower odds of OB than males without ADHD Unmedicated males (ADHD) as likely as males (no ADHD) to be OB No difference in odds of OB in females (medication for ADHD) did not differ statistically from females (no ADHD) Females (ADHD, no medication) had odds of OB 1.54× females without ADHD (not statistically significant)
Cortese et al^Citation33	2007	Cross-sectional	12–17	99	Severely OB adolescents, France	OW >97th percentile (national BMI charts) Assessed pediatrician: Eating behaviors: Bulimic Inventory BDI, STAI: depression/anxiety CPRS: ADHD symptoms Tanner stages: puberty	OB significantly associated (ADHD) symptoms (after controlling for depressive/anxiety) ADHD symptom/bulimic behaviors associated in OB adolescents may be accounted for by impulsivity/inattention rather than hyperactivity
Duarte et al^Citation31	2010	Prospective/population-based (national) Recruited – R Assessed – A	R: 8 A: 18–23	2,209	Military examination records, boys, Finland	BMI (military records). Child mental health (8 years) assessed through 3 sources: parents, teachers, and children Parent–teacher – psychopathy using Rutter scale: conduct, hyperkinetic (related to hyperactivity, inattentive behavior, etc) and emotional domains CDI: depression	Childhood conduct problems (disobedience/defiance/aggression/cruelty to others/stealing/lying/destruction of property) prospectively associated with OW/OB young adults
Dubnov-Raz et al^Citation34	2011	Cross-sectional Medical records analysis	6–16	275	Diagnosed ADHD treated (methylphenidate, per guidelines) with no neurological comorbidities, confirmed healthy controls, Israel	BMI, z-scores (OW as ≥85th percentile, OB as ≥95th percentile growth charts, CDCAP) Diagnosis – DSM-IV-TR Medication or no medication	OW/OB prevalence was lower in ADHD-treated group compared with healthy controls, similar to national estimates Methylphenidate treatment did not significantly alter OW status
Erhart et al^Citation35	2012	Cross-sectional/community-based survey	11–17	2,863	German parents/children	BMI (national age/sex-specific referencevalues) Diagnosis: DSMMD-based German ADHD scale	Rate of ADHD significantly higher for OB than normal/UW children. OW/OB children 2× likely for ADHD diagnosis
Graziano et al^Citation39	2012	Cohort	4.5–18	80	ADHD (diagnosed and clinical confirmation), hospital clinic, US	BMI, z-scores (age-sex centiles-CDCAP) ADHD: DSM-IV for diagnosis Treatment history: internalizing, hyperactivity/impulsivity/learning problems; externalizing factors – defiance, aggression, peer relations CPRS	Children (ADHD): Performing poorly on neuropsychological battery had higher BMI z-scores and more likely to be classified as OW/OB compared with children with ADHD performing better on tests On stimulant medication, had lower BMI z-score EF more impaired and co-occurring weight problems
Khalife et al^Citation32	2014	Prospective/Postal/questionnaire	7–8 16	8,106 6,934	1986 birth-cohort, Finland	BMI (OB defined, IOTF cutoff points) Age 7–8: ADHD/CD symptoms (teacher)/Normal Behavior Scale, BMI/PA (parents) Age 16: ADHD symptoms (parents/SWAN)/PA index of binge eating (self)	Children (ADHD/CD symptom) increased risk of OB and physically inactive adolescents PA may be beneficial for behavior problems/OB High comorbidity between inattention-hyperactivity/CD symptoms Variables significantly associated over-time until 16 years, for BMI/inattention symptoms 16 years slight negative association between BMI/PA BMI/eating-related
Kim et al^Citation36	2011	Cross-sectional national survey	6–17	66,707	US children	BMI (as ≥95th percentile growth charts, CDCAP) Integrated telephone survey with parents (US Department of Health and Human Services) ADHD (assessed as parental response to ADHD questions) Depression/anxiety	OB prevalence higher among children with ADHD ADHD medication had protection effect against weight gain Odds of being OB higher in girls than boys in nonmedicated ADHD compared with medicated ADHD Only health behaviors (sports and not sleeping) associated with OB in boys with ADHD (on medication)
*Marks et al^Citation5	2009	Retrospective medical record review	4–21	230 Weight only for 121	Individuals (psychiatric consultation), US	BMI (CNRC guidelines) Major psychiatric diagnosis recorded: BP, ADHD, depression	OW/OB children No statistically significant difference in rates of most common psychiatric disorders (ie ADHD, BP disorder/depression) Rates of depression/BP disorder higher than normal/UW children Trend to increasing rates of conduct disorders
Pauli-Pott et al^Citation42	2014	Documentary analysis	6–12	360	ADHD, ODD, CD, or adjustment disorder (n=257) and control group with adjustment disorder (n=103), Germany	BMI (OB classified ≥97th percentile national reference data) ICD-10: diagnosis disturbances of activity and attention, and hyperkinetic conduct disorder	Nonsignificant links between ADHD/BMI-SDS or obesity Children with ODD/CD had highest body weight and highest rate of OB irrespective of ADHD diagnosis No independent link between ADHD and OB
Racicka et al^Citation43	2015	Documentary analysis	7–18	408	ADHD patients, Poland	BMI (age/sex-growth references, Polish population) ADHD: diagnosis by child psychiatrists using DSM-IV	Significantly higher frequency of OW/OB patients with ADHD than general population Higher incidence of OB with comorbidities of adjustment disorder
Rojo et al^Citation40	2006	Community study	13–15	35,403	Obese adolescents	Self-reported (study limitation): BMI (OW 90%–97%; OB >97th percentile) SDQ ADHD characteristics, conduct, hyperactivity Depression/anxiety	Slight increase only in comorbidity of ADHD characteristics in OB adolescents
Waring et al^Citation37	2008	Cross-sectional national survey	5–17	62,887	ADHD (2004 national child health survey– using SLAITS), US	BMI (defined percentile growth charts, CDCAP) Diagnosis ADHD – trained interviewers Medication/no medication	Children (ADHD) not using medication had 1.5× odds of being OW Children/adolescents (ADHD) on medication had 1.6× odds of being UW compared with children/adolescents without diagnosis
White et al^Citation44	2012	Cohort-secondary analysis	5/10/30	> 12,400	UK, 1970s/birth-cohort study	BMI (UK standards) Behavior over 5–10 years: RPS CPRS SDC Ml	General psychological problems consistently associated in childhood particularly hyperactivity and attention problem with adult OB Further associations with disruptive behavior tapping into conduct problems/impulsivity/hyperactivity OB associated with persistent psychological problems across childhood (problems: early childhood at greater risk) No evidence: maternal psychological problems associated with OB risk in offspring
Yang et al^Citation41	2013	Cohort	6–16	158	ADHD children (meeting DSM-IV criteria), People's Republic of China	BMI, z-scores (NGRCCA) Diagnosed ADHD, Dl CPTRS Physical assessment, eg, pubertal development	Increased incidence of OB children with ADHD (higher in general population) Children (combined ADHD/onset of puberty) at higher risk of becoming OW/OB

Notes: Refer to Table 6 for abbreviations and outcome measures.

* Also cited in Table 3.

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