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CASE REPORT

Successful Treatment of Severe Subcorneal Pustular Dermatosis with Adalimumab

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Pages 2567-2570 | Received 28 Sep 2022, Accepted 10 Nov 2022, Published online: 28 Nov 2022

Figures & data

Figure 1 (A) Multiple erythemas and pustules with central clearing and crusted edge located on the face, trunk, and extremities upon initial evaluation. (B) Regression of skin lesions one week after treatment with Adalimumab (80mg/week). (C and D) Regression of skin lesions three weeks and six weeks after treatment with Adalimumab.

Figure 1 (A) Multiple erythemas and pustules with central clearing and crusted edge located on the face, trunk, and extremities upon initial evaluation. (B) Regression of skin lesions one week after treatment with Adalimumab (80mg/week). (C and D) Regression of skin lesions three weeks and six weeks after treatment with Adalimumab.

Figure 2 The Subcorneal pustule is composed predominantly of neutrophils, with spongiosis in the granular layer and upper spine layer, and infiltration of neutrophils and lymphocytes in the superficial dermis. (Hematoxylin and eosin; magnifications: (A) ×40, (B) ×200).

Figure 2 The Subcorneal pustule is composed predominantly of neutrophils, with spongiosis in the granular layer and upper spine layer, and infiltration of neutrophils and lymphocytes in the superficial dermis. (Hematoxylin and eosin; magnifications: (A) ×40, (B) ×200).