Budget Impact Analysis of Switching to Rituximab’s Biosimilar in Rheumatology and Cancer in 13 Countries Within the Middle East and North Africa

Figures & data

Table 1 Dosing Regimens of Rituximab in All Approved Indications

Therapeutic Indication	Schedule	Rituximab Dose	Total RTX Consumption per Patient (mg)
Rheumatoid arthritis	One dose per 6 months	4 x 500 mg	4000.00
First line NHL	Day 1 of each cycle of chemotherapyx8	375 mg/m^2	5370.00
First line CLL	For 6 cycles
	Day prior to the first cycle of chemotherapy	375 mg/m^2	5146.25
	Day 1 of cycles 2–6 every 28 days	500D mg/m^2

Abbreviations: NHL, non Hodgkin’s lymphoma; CLL, chronic lymphocytic leukemia; RTX, Rituximab; m², square meter.

Figure 1 The estimation model and weights for the budget impact analysis study. Weightings were calculated according to the following formula: where j is the incidence rate of indication j. consumption per year j is the total need of milligrams for the treatment of indication j. rituximab treatment rate is the proportion of patients treated in indication j treated with rituximab.

Abbreviations: RA, rheumatoid arthritis; NHL, Non-Hodgkin’s lymphoma; CLL, chronic lymphocytic leukemia.

Table 2 A Projection of Total Budget Impact Savings Related to the Introduction of a Rituximab Biosimilar Over a 1-Year Period in Addition to the Number of Patients That Would Benefit from Gaining Accessibility to Rituximab Treatment

Country	RA		NHL		CLL		Other Indications		Total
	Budget Impact. Million $	No. of Patients	Budget Impact. Million $	No. of Patients	Budget Impact. Million $	No. of Patients	Budget Impact. Million $	No. of Patients	Budget Impact. Million $	No. of Patients
KSA	−1.04‬	144	−2,08	215	−1.77	191	−0.54	356	5.43	906
Libya	−0.86‬	11	−0.17	22	−0.19	25	−0.50	41	1.72	99
Qatar	−0.71	10	−0.23	16	−0.20	14	−0.60	26	1,74	66
Bahrain	−0.72	10	−0.17‬	17	−0.12	12	−0.39	26	1.4	65
Tunisia	−0.27	44	−0.97	75	−0.73	59	−0.21	102	2.18	280
Oman	−0.89	8	−0.20	21	−0.14‬	15	−0.48	31	1.71	75
Algeria	−1.06	176	−3.49	413	−2.86	352	−0.88	669	8.29	1610
UAE	−0.18‬	25	−0.41	41	−0.31‬	32	−0.99	65	1.89	163
Kuwait	−0.15‬	21	−0.34	35	−0.28	30	−0.86	56	1.63	142
Morocco	−0.97	167	−4.01	329	−2.07‬	177	−0.84	440	7.89	1113
Lebanon	−0.39	62	−3.14	127	−1.41	58	−0.63	160	7.31	407
Jordan	0.18‬	40	−0.48	58	−0.55	65	−0.14	106	1.35	269
Iraq	−1,05	207	−1.78	266	−2.38 ‬	367	−0.58	550	5.79	1390
Total	−7.06	925	−15.39	1635	−13.01	1397	−7.64	2628	46.59	6585

Abbreviation: $, United States dollar.