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Review

Diagnostic Accuracy Of Fecal Occult Blood Tests For Detecting Proximal Versus Distal Colorectal Neoplasia: A Systematic Review And Meta-Analysis

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 943-954 | Published online: 25 Oct 2019

Figures & data

Figure 1 Flow chart of search strategy and selection of reports (search until August 20, 2018).

Figure 1 Flow chart of search strategy and selection of reports (search until August 20, 2018).

Table 1 Characteristics Of Included Studies In This Review

Figure 2 Forest plots for the pooled sensitivities of guaiac-fecal occult blood test on the detection of colorectal neoplasms, (A) for detecting proximal colorectal cancer; (B) for detecting distal colorectal cancer; (C) for detecting proximal advanced adenoma; d) for detecting distal advanced adenoma; (E) for detecting proximal advanced neoplasia; (F) for detecting distal advanced neoplasia.

Note: aOrdinal numbers were applied to mark the studies which contain variable FOBT brands.
Figure 2 Forest plots for the pooled sensitivities of guaiac-fecal occult blood test on the detection of colorectal neoplasms, (A) for detecting proximal colorectal cancer; (B) for detecting distal colorectal cancer; (C) for detecting proximal advanced adenoma; d) for detecting distal advanced adenoma; (E) for detecting proximal advanced neoplasia; (F) for detecting distal advanced neoplasia.

Figure 3 Forest plots for the pooled sensitivities of immunochemical fecal occult blood test on the detection of colorectal neoplasms, (A) for detecting proximal colorectal cancer; (B) for detecting distal colorectal cancer; (C) for detecting proximal advanced adenoma; (D) for detecting distal advanced adenoma; (E) for detecting proximal advanced neoplasia; (F) for detecting distal advanced neoplasia.

Note: aOrdinal numbers were applied to mark the studies which contain variable FOBT brands.
Figure 3 Forest plots for the pooled sensitivities of immunochemical fecal occult blood test on the detection of colorectal neoplasms, (A) for detecting proximal colorectal cancer; (B) for detecting distal colorectal cancer; (C) for detecting proximal advanced adenoma; (D) for detecting distal advanced adenoma; (E) for detecting proximal advanced neoplasia; (F) for detecting distal advanced neoplasia.

Figure 4 Comparison of SROCs for detecting colorectal neoplasms located in the proximal and distal colon/rectum, (A) for detecting colorectal cancer using guaiac-fecal occult blood test; (B) for detecting colorectal cancer using immunochemical fecal occult blood test; (C) for detecting advanced adenoma using guaiac-fecal occult blood test; (D) for detecting advanced adenoma using immunochemical fecal occult blood test; (E) for detecting advanced neoplasia using guaiac-fecal occult blood test; (F) for detecting advanced neoplasia using immunochemical fecal occult blood test.

Abbreviations: gFOBT, guaiac-fecal occult blood testing; iFOBT, immunochemical fecal occult blood testing.
Figure 4 Comparison of SROCs for detecting colorectal neoplasms located in the proximal and distal colon/rectum, (A) for detecting colorectal cancer using guaiac-fecal occult blood test; (B) for detecting colorectal cancer using immunochemical fecal occult blood test; (C) for detecting advanced adenoma using guaiac-fecal occult blood test; (D) for detecting advanced adenoma using immunochemical fecal occult blood test; (E) for detecting advanced neoplasia using guaiac-fecal occult blood test; (F) for detecting advanced neoplasia using immunochemical fecal occult blood test.