Interleukin-6 and airflow limitation in chemical warfare patients with chronic obstructive pulmonary disease

Figures & data

Table 1 Demographic and clinical parameters of lung function in 50 patients with chronic obstructive pulmonary disease as a late pulmonary complication of sulfur mustard poisoning

Parameters	Values
Age (years)	46.3 ± 9.18
Duration of disease (years)	17.00 ± 6.00
FEV1 (% predicted)	58.98 ± 17.51
FEV1/FVC	62.14 ± 9.70
6MWT (minutes)	327.8 ± 86.96
BMI	27.32 ± 3.30
PaO2 (mmHg)	75.1 ± 12.00
SaO2 (%)	94.03 ± 3.45
PaCO2 (mmHg)	37.55 ± 9.50
Total SGRQ score	56.23 ± 14.31
IL-6 (pg/mL)	15.01 ± 0.61
Inhaled corticosteroid therapy (% of patients)	42

Note: The data are presented as the mean ± SD.

Abbreviations: FEV₁, forced expiratory volume in one second; FVC, forced vital capacity; 6MWT, 6-minute walk test; BMI, body mass index; P_aO₂, arterial oxygen tension; S_aO₂, arterial oxygen saturation; P_aCO₂, arterial carbon dioxide tension; SGR Q, St George’s Respiratory Questionnaire; IL-6, interleukin-6; SD, standard deviation.

Figure 1 The frequency of GOLD stages in 50 chemical warfare patients with chronic obstructive pulmonary disease as a late pulmonary complication of sulfur mustard poisoning.

Abbreviation: GOLD, Global Initiative for Chronic Obstructive Lung Disease.

Figure 2 Comparison of serum interleukin-6 between patients and controls.

Abbreviation: IL-6, interleukin 6.

Table 2 Correlation of serum interleukin-6 with lung function parameters in 50 patients with late pulmonary complications of sulfur mustard poisoning

Variable	Correlation coefficient (r)	P value
Age	0.06	0.71
BMI	0.21	0.16
Duration of disease	0.70	0.60
FEV1 (% predicted)	−0.36	0.016
GOLD	0.25	0.04
PaO2	−0.06	0.70
PaCO2	0.08	0.61
MMRC	0.17	0.27
6MWT	−0.02	0.02
BODE	0.38	0.01
Total SGRQ score	0.90	0.23

Abbreviations: BMI, body mass index; FEV₁, forced expiratory volume in one second; GOLD, Global Initiative for Chronic Obstructive Lung Disease; P_aO₂, arterial oxygen tension; P_aCO₂, arterial carbon dioxide tension; MMRC, Modified Medical Research Council; 6MWT, 6-minute walk test; BODE, body mass index, obstruction, dyspnea, and exercise capacity; SGRQ, St George’s Respiratory Questionnaire.

Figure 3 Correlation of serum IL-6 and FEV₁ percent predicted (r = −0.36, P = 0.016).

Abbreviations: IL-6, Interleukin 6; FEV₁, forced expiratory volume in one second.

Figure 4 Correlation of serum interleukin-6 and BODE index (r = 0.38, P = 0.01).

Abbreviations: IL-6, Interleukin 6; BODE, Body mass index, Obstruction, Dyspnea, Exercise.