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Original Research

Multicenter study of the COPD-6 screening device: feasible for early detection of chronic obstructive pulmonary disease in primary care?

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Pages 2323-2331 | Published online: 04 Aug 2017

Figures & data

Table 1 Baseline characteristics of all enrolled subjects (n=2,990) and classification according to whether participants were only screened with COPD-6 test (n=2,041) or proceeded to confirmative spirometry (n=949)Table Footnotea

Figure 1 CONSORT diagram of enrolled subjects.

Notes: The following diagnostic criteria were applied: 1) COPD: post-bronchodilator (BD) FEV1/FVC <0.7 and <0.5 L post-BD increase in FEV1, 2) asthma: post-BD FEV1 increase ≥0.5 L, and 3) no obstructive lung disease, that is, not fulfilling any of these criteria.
Abbreviations: COPD, chronic obstructive pulmonary disease; FEV, forced expiratory volume; FVC, forced vital capacity; MD, medical doctor’s.
Figure 1 CONSORT diagram of enrolled subjects.

Table 2 Prevalence of airway obstruction (FEV1/FVC <0.70) at the COPD-6 test and at pre- and post-bronchodilator spirometry according to criteria for performing confirmative spirometry

Figure 2 Prevalence of final diagnosis, that is, COPD, asthma, or no obstructive lung disease, according to the three different criteria for proceeding to confirmative spirometry.

Notes: Criteria for, 1) COPD: post-bronchodilator (BD) FEV1/FVC <0.7 and ΔFEV1 <0.5 L at BD reversibility test; 2) asthma: ΔFEV1 ≥0.5 L at BD reversibility test; Non-OLD: not fulfilling criteria 1) or 2). MD decision: MD decision to perform confirmative spirometry based on suspicion of COPD and an FEV1/FVC ratio close to 0.7. Subjects with both FEV1/FEV6 ratio <0.7 and FEV1 <80% were counted in the group “FEV1/FEV6 ratio <0.7”.

Abbreviations: FEV, forced expiratory volume; FVC, forced vital capacity; MD, medical doctor’s; OLD, obstructive lung disease.

Figure 2 Prevalence of final diagnosis, that is, COPD, asthma, or no obstructive lung disease, according to the three different criteria for proceeding to confirmative spirometry.Notes: Criteria for, 1) COPD: post-bronchodilator (BD) FEV1/FVC <0.7 and ΔFEV1 <0.5 L at BD reversibility test; 2) asthma: ΔFEV1 ≥0.5 L at BD reversibility test; Non-OLD: not fulfilling criteria 1) or 2). MD decision: MD decision to perform confirmative spirometry based on suspicion of COPD and an FEV1/FVC ratio close to 0.7. Subjects with both FEV1/FEV6 ratio <0.7 and FEV1 <80% were counted in the group “FEV1/FEV6 ratio <0.7”.Abbreviations: FEV, forced expiratory volume; FVC, forced vital capacity; MD, medical doctor’s; OLD, obstructive lung disease.

Figure 3 Comparison of the FEV1/FEV6 ratio for subjects with airway obstruction (defined as FEV1/FEV6 <0.70) at the COPD-6 test (A) (n=510) with the FEV1/FVC ratio at the subsequent post-BD spirometry (B).

Abbreviations: BD, bronchodilator; FEV, forced expiratory volume; FVC, forced vital capacity.
Figure 3 Comparison of the FEV1/FEV6 ratio for subjects with airway obstruction (defined as FEV1/FEV6 <0.70) at the COPD-6 test (A) (n=510) with the FEV1/FVC ratio at the subsequent post-BD spirometry (B).

Table 3 Characteristics of subjects diagnosed with COPD compared to subjects diagnosed with asthma and no obstructive lung disease (no OLD)Table Footnotea,Table Footnoteb

Table 4 Spirometry data grouped by selection criteria for confirmative spirometry