A pre–post intervention study of pulmonary rehabilitation for adults with post-tuberculosis lung disease in Uganda

Figures & data

Table 1 Background characteristics of p-TBLD patients (n=29)

Characteristics	Value
Gender – female, n (%)	14 (51.7)
Age group (years), n (%)
17–35	6 (20.7)
36–50	13 (44.8)
51–69	10 (34.5)
Age in years, mean (SD)	45 (13)
Highest level education, n (%)
None/incomplete primary	11 (37.9)
Complete primary/incomplete secondary	9 (31)
Complete secondary/tertiary	9 (31)
Occupation, n (%)
Unemployed	9 (31)
Others	20 (69)
Ever smoked, n (%)	10 (34.5)
If smoked, duration smoked in years, median (IQR)	15.5 (18)
Exposed to biomass, n (%)	12 (41.4)
If exposed to biomass
Number of hours exposed per day, median (IQR)	2 (2)
Number of years exposed, median (IQR)	10 (15)

Abbreviations: p-TBLD, post-tuberculosis lung disorder; IQR, interquartile range.

Table 2 Baseline spirometric data on 29 participants

Variables	Prebronchodilator, mean (SD)	Postbronchodilator, mean (SD)
FEV1 (L)	1.40 (0.56)	1.42 (0.54)
FEV1 %	56.8 (25.0)	58.1 (25.2)
FVC (L)	2.08 (0.60)	2.13 (0.61)
FVC%	70.4 (21.8)	72.0 (21.63)
FEV:FVC	0.68 (0.19)	0.67 (0.19)

Abbreviations: FEV₁, forced expiratory volume in 1 second; FEV₁%, forced expiratory volume in 1 second as a percentage of predicted; FVC, forced vital capacity; FVC%, forced vital capacity as a percentage of predicted.

Table 3 Mean (95% CI) of health status, exercise capacity, and biometric outcomes for 29 participants who completed data collection at all three time points

Outcome measures	Baseline	End of PR	Change from baseline to end of PR	6 weeks after end of PR	Change from baseline to 6 weeks after end of PR
CCQ total score	1.88 (1.59, 2.17)	0.93 (0.76, 1.10)	−0.95 (−1.18, −0.72)	0.79 (0.63, 0.96)	−1.09 (−1.34, −0.83)
CCQ symptom score	2.03 (1.69, 2.38)	1.10 (0.88, 1.33)	−0.93 (−1.23, −0.63)	0.95 (0.71, 1.19)	−1.08 (−1.39, −0.79)
CCQ mental state score	1.98 (1.49, 2.47)	0.76 (0.47, 1.04)	−1.22 (−1.56, −0.89)	0.52 (0.33, 0.70)	−1.46 (−1.96, −0.97)
CCQ functional state score	1.67 (1.40, 1.95)	0.84 (0.69, 1.00)	−0.83 (−1.08, −0.57)	0.77 (0.60, 0.93)	−0.90 (−1.16, −0.65)
PHQ-9 total score	3.24 (1.24, 5.24)	0.03 (−0.04, 0.11)	−3.21 (−5.10, −1.31)	0.07 (−0.07, 0.21)	−3.17 (−5.05, −1.29)
Karnofsky score	75.86 (73.70, 78.02)	89.66 (88.05, 91.26)	13.79 (12.00, 15.59)	90.34 (88.19, 92.50)	14.48 (11.8, 17.19)
ISWT (m)	312.41 (275.95, 348.88)	402.41 (357.74, 447.08)	90.00 (56.50, 123.50)	402.07 (353.84, 450.29)	89.66 (49.32, 129.99)
Borg score after ISWT	6.48 (5.68, 7.28)	4.36 (3.55, 5.17)	−2.12 (−2.98, −1.26)	4.52 (3.65, 5.39)	−1.96 (−2.93, −1.00)
Sit-to-stand time (seconds)	10.45 (9.29, 11.61)	7.90 (7.01, 8.78)	−2.55 (−3.69, −1.41)	7.03 (6.53, 7.54)	−3.42 (−4.46, −2.37)
BMIa (kg/m^2)	20.86 (18.92, 22.81)	21.49 (19.59, 23.40)	0.63 (0.23, 1.03)	21.77 (19.92, 23.61)	0.91 (0.42, 1.39)
Mid upper arm circumference (cm)	25.27 (23.83, 26.72)	25.33 (23.10, 27.56)	0.06 (−1.64, 1.75)	25.92 (24.46, 27.39)	0.65 (0.21, 1.10)

Note:

a Based on 28 patients.

Abbreviations: CI, confidence interval; PR, pulmonary rehabilitation; CCQ, Clinical COPD Questionnaire; PHQ-9, Patient Health Questionnaire-9; ISWT, Incremental Shuttle Walking Test; BMI, body mass index.

Table 4 Number (%) of participants reporting cough, chest pains, and hemoptysis in 29 p-TBLD participants who completed data collection at all three time-points

Symptoms	Summary measure	Number (%) at time
		Baseline	End of PR	6 weeks after end of PR
Experience pain in chest?	Yes	13 (44.8)	9 (31)	7 (24.1)
Suffer from hemoptysis?	Yes	5 (17.2)	2 (6.9)	2 (6.9)
Have cough?	None	17 (58.6)	14 (48.3)	17 (58.6)
	Mild	8 (27.6)	14 (48.3)	10 (34.5)
	Moderate	4 (13.8)	1 (3.4)	2 (6.9)
	Severe	0	0	0

Abbreviations: p-TBLD, post-tuberculosis lung disorder; PR, pulmonary rehabilitation.

Figure 1 Mean chest pain severity scores before, after and six weeks after PR (n=29).

Abbreviation: PR, pulmonary rehabilitation.