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Original Research

Effect of Inhaled Corticosteroid Withdrawal on Chronic Obstructive Pulmonary Disease Exacerbations in Patients Taking Triple Therapy at Baseline

, ORCID Icon, , ORCID Icon, &
Pages 2879-2888 | Published online: 11 Nov 2020

Figures & data

Figure 1 WISDOM trial design.

Abbreviations: BID, twice daily; ICS, inhaled corticosteroids; QD, once daily.
Figure 1 WISDOM trial design.

Table 1 Disease and Patient Characteristics at Screening (Patients Taking Triple Therapy at Screeninga and the Overall Trial Population)

Table 2 Time to First COPD Exacerbation and Number of COPD Exacerbations (in Patients Taking Triple Therapy at Screeninga and in the Overall Trial Population)

Figure 2 Kaplan–Meier estimates of the probability of no moderate or severe on-treatment COPD exacerbation in (A) patients taking triple therapy at screening and (B) overall trial population.

Abbreviations: CI, confidence interval; COPD, chronic obstructive pulmonary disease; ICS, inhaled corticosteroids.
Figure 2 Kaplan–Meier estimates of the probability of no moderate or severe on-treatment COPD exacerbation in (A) patients taking triple therapy at screening and (B) overall trial population.

Figure 3 Kaplan–Meier estimates of the probability of no severe on-treatment COPD exacerbation in (A) patients taking triple therapy at screening and (B) overall trial population.

Abbreviations: CI, confidence interval; COPD, chronic obstructive pulmonary disease; ICS, inhaled corticosteroids.
Figure 3 Kaplan–Meier estimates of the probability of no severe on-treatment COPD exacerbation in (A) patients taking triple therapy at screening and (B) overall trial population.

Figure 4 Forest plot of time to first moderate or severe COPD exacerbation in (A) patients taking triple therapy at screening and (B) overall trial population.

Abbreviations: 6-MWT, 6-minute walk test; BMI, body mass index; COPD, chronic obstructive pulmonary disease; ICS, inhaled corticosteroids.
Figure 4 Forest plot of time to first moderate or severe COPD exacerbation in (A) patients taking triple therapy at screening and (B) overall trial population.

Figure 5 Percentage of patients with at least one moderate or severe COPD exacerbation (in patients taking triple therapy at screeninga and in the overall trial population).

Notes: aBefore the run-in period where all patients took triple therapy; The numbers above the bars indicate percentages of patients with at least one exacerbation during the study; *Indicates the ratio of the percentages of patients with at least one exacerbation within the ICS continuation and ICS withdrawal groups.
Abbreviations: COPD, chronic obstructive pulmonary disease; FEV1, forced expiratory volume in 1 second; eos, blood eosinophil counts; exc, exacerbations; ICS, inhaled corticosteroids.
Figure 5 Percentage of patients with at least one moderate or severe COPD exacerbation (in patients taking triple therapy at screeninga and in the overall trial population).