Efficacy and safety of eco-friendly inhalers: focus on combination ipratropium bromide and albuterol in chronic obstructive pulmonary disease

Figures & data

Figure 1 Maps of the hole in the Antarctic ozone layer demonstrating its enlargement over time.

Note: Reproduced from Ozone hole through the years [web page on the Internet]. Greenbelt MD. Earth Observatory; 2011. Available from: http://earthobservatory.nasa.gov/IOTD/view.php?id=49040. Accessed Dec 2012.¹⁵

Figure 2 Configuration of the prototype for the Respimat® Soft Mist Inhaler™. (Boehringer Ingelheim, Ingelheim, Germany).

Note: Dalby RN, Eicher J, Zierenberg B. Development of Respimat(®) Soft Mist™ Inhaler and its clinical utility in respiratory disorders. Med Devices (Auckl). 2011;4:145–155.²⁹

Figure 3 Internal configuration of the uniblock showing the linear flow channels that direct the medication solution to two symmetric exit ports that focus the solution jets into a precisely configured convergence to produce aerosolized droplets that exit the nozzle outlet.

Note: Reproduced from Dalby RN, Eicher J, Zierenberg B. Development of Respimat(®) Soft Mist™ Inhaler and its clinical utility in respiratory disorders. Med Devices (Auckl). 2011;4:145–155.²⁹

Figure 4 Internal mechanism of the Respimat® Soft Mist Inhaler™. (Boehringer Ingelheim, Ingelheim, Germany).

Notes: To activate the device, the base is twisted 180°, which turns a helical cam gear that compresses and loads the spring and moves a capillary tube with a one-way valve into the solution cartridge, thereby pulling fluid into the dosing chamber. When the dose-release button is pressed, the spring releases, pushing the capillary tube toward the uniblock, shutting the one-way valve, and turning the capillary tube into a piston that forces the solution through the uniblock.Reproduced from Dalby RN, Eicher J, Zierenberg B. Development of Respimat(®) Soft Mist™ Inhaler and its clinical utility in respiratory disorders. Med Devices (Auckl). 2011;4:145–155.²⁹

Ozone hole through the years [web page on the Internet]Greenbelt, MDEarth Observatory2011 Available from: http://earthobservatory.nasa.gov/IOTD/view.php?id=49040Accessed Dec 2012

 Google Scholar

HarrisonEChange in the air. Banning CFC-driven inhalers could levy a toll on asthma sufferersSci Am200829922022

 Google Scholar