Updates on the COPD gene list

Figures & data

Table 1 List of genes associated with chronic obstructive pulmonary disease

Symbol	Name	Chromosome	References
			Single studies		Meta-analyses
			Positive	Negative	Positive	Negative
A2M	Alpha-2-macroglobulin	12	^Citation51
ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	16	^Citation52^–^Citation54
ACE	Angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	17	^Citation55^–^Citation60	^Citation61,Citation62		^Citation5
ADAM33	ADAM metallopeptidase domain 33	20	^Citation63^–^Citation68	^Citation69,Citation70
ADRB2	Adrenergic, beta-2-, receptor, surface	5	^Citation71^–^Citation82	^Citation83		^Citation5,Citation83
ALOX5AP	Arachidonate 5-lipoxygenase-activating protein	13	^Citation84
AQP5	Aquaporin 5	12	^Citation85,Citation86
BCL2	B-cell CLL/lymphoma 2	18	^Citation87
BDKRB2	Bradykinin receptor B2	14	^Citation88
CASP10	Caspase 10, apoptosis-related cysteine peptidase	2	^Citation89
CAT	Catalase	11	^Citation90	^Citation91,Citation92
CCL5 (RANTES)	Chemokine (C-C motif) ligand 5	17	^Citation93	^Citation79
CCR2	Chemokine (C-C motif) receptor 2	3	^Citation94
CD14	CD14 molecule	5	^Citation95,Citation96
CD40	CD40 molecule, TNF receptor superfamily member 5	20	^Citation97
CD63	CD63 molecule	12	^Citation98
CD86	CD86 molecule	3	^Citation99
CDC6	Cell division cycle 6 homolog (S cerevisiae)	17	^Citation100
CDKN1A (p21)	Cyclin-dependent kinase inhibitor 1A (p21, Cip1)	6	^Citation101
CFTR	Cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	7	^Citation102^–^Citation108	^Citation109,Citation110
CHI3L1	Chitinase 3-like 1 (cartilage glycoprotein-39)	1	^Citation111
CHRNA3	Cholinergic receptor, nicotinic, alpha 3 (neuronal)	15	^Citation26,Citation30,Citation31, ^Citation112,Citation113
CHRNA5	Cholinergic receptor, nicotinic, alpha 5 (neuronal)	15	^Citation26,Citation30,Citation31, ^Citation112,Citation113
CLCA1	Chloride channel accessory 1	1	^Citation114
COL4A3	Collagen, type IV, alpha 3 (Goodpasture antigen)	2	^Citation115
CRP	C-reactive protein, pentraxin-related	1	^Citation116	^Citation117^–^Citation119
CSF2	Colony stimulating factor 2 (granulocyte-macrophage)	5	^Citation120	^Citation121
CSF3	Colony stimulating factor 3 (granulocyte)	17	^Citation121
CTLA4	Cytotoxic T-lymphocyte-associated protein 4	2	^Citation99,Citation122,Citation123
CTSS	Cathepsin S	1	^Citation124
CYBA	Cytochrome b-245, alpha polypeptide	16	^Citation125
CYP1A1	Cytochrome P450, family 1, subfamily A, polypeptide 1	15	^Citation125^–^Citation128	^Citation129,Citation130
CYP1A2	Cytochrome P450, family 1, subfamily A, polypeptide 2	15	^Citation129,Citation131	^Citation125,Citation128
CYP2E1	Cytochrome P450, family 2, subfamily E, polypeptide 1	10	^Citation127,Citation132	^Citation130
CYP2F1	Cytochrome P450, family 2, subfamily F, polypeptide 1	19	^Citation133
CYP3A5	Cytochrome P450, family 3, subfamily A, polypeptide 5	7	^Citation134
DEFB1	Defensin, beta 1	8	^Citation135,Citation136	^Citation137
DEFB4A	Defensin, beta 4A	8	^Citation138
EDN1	Endothelin 1	6	^Citation139^–^Citation141	^Citation142,Citation143
EDNRB	Endothelin receptor type B	13	^Citation143
ELN	Elastin (supravalvular aortic stenosis, Williams–Beuren syndrome)	7	^Citation144,Citation145	^Citation146,Citation147
EPHX1	Epoxide hydrolase 1, microsomal (xenobiotic)	1	^Citation77,Citation83,Citation130, ^Citation146^–^Citation167	^Citation127,Citation168^–^Citation174	^Citation175	^Citation5,Citation8,Citation176
ESR1	Estrogen receptor 1	6	^Citation177
FAM13A	Family with sequence similarity 13, member A	4	^Citation26
FGF10	Fibroblast growth factor 10	5	^Citation178
GC	Group-specific component (vitamin D binding protein)	4	^Citation179^–^Citation186	^Citation146,Citation147,Citation151, ^Citation155,Citation187
GCLC	Glutamate-cysteine ligase, catalytic subunit	6	^Citation188	^Citation172,Citation189
GCLM	Glutamate-cysteine ligase, modifier subunit	1	^Citation190	^Citation172,Citation188
GSTCD	Glutathione S-transferase, C-terminal domain containing	4	^Citation191
GSTM1	Glutathione S-transferase M1	1	^Citation127,Citation148,Citation161, ^Citation164,Citation165, ^Citation192^–^Citation202	^Citation90,Citation130,Citation146,Citation147, ^Citation151,Citation169,Citation203^–^Citation206	^Citation5,Citation7,Citation8
GSTO1	Glutathione S-transferase omega 1	10	^Citation207
GSTO2	Glutathione S-transferase omega 2	10	^Citation207
GSTP1	Glutathione S-transferase pi 1	11	^Citation77,Citation90,Citation146, ^Citation148,Citation151,Citation152, ^Citation157,Citation164,Citation165, ^Citation193,Citation194,Citation196, ^Citation204,Citation208^–^Citation210	^Citation69,Citation127,Citation130,Citation147, ^Citation149,Citation159,Citation171,Citation185, ^Citation197,Citation203,Citation211,Citation212	^Citation8,Citation213	^Citation5,Citation214
GSTT1	Glutathione S-transferase theta 1	22	^Citation127,Citation165,Citation193, ^Citation196^–^Citation198, ^Citation204^–^Citation206	^Citation90,Citation130,Citation148,Citation161, ^Citation164,Citation169,Citation194, ^Citation199^–^Citation201,Citation203		^Citation5,Citation7,Citation8
HCK	Hemopoietic cell kinase	20	^Citation215
HHIP	Hedgehog interacting protein	4	^Citation26,Citation191,Citation216
HLA	Classical class 11 subregion of the MHC	6	^Citation217,Citation218	^Citation219,Citation220
HMOX1	Heme oxygenase (decycling) 1	22	^Citation130,Citation151,Citation166, ^Citation221^–^Citation224	^Citation69,Citation147,Citation185, ^Citation196,Citation225
HTR4	5-hydroxytryptamine (serotonin) receptor 4	5	^Citation191
IFNG	Interferon, gamma	12	^Citation226^–^Citation228
IL1A	Interleukin 1, alpha	2	^Citation227
IL1B	Interleukin 1, beta	2	^Citation227,Citation229^–^Citation233	^Citation120,Citation228, ^Citation234^–^Citation238		^Citation5,Citation8
IL1RN	Interleukin 1 receptor antagonist	2	^Citation231,Citation232, ^Citation234,Citation235	^Citation228,Citation230, ^Citation236^–^Citation238	^Citation8
IL2	Interleukin 2	4	^Citation227
IL27	Interleukin 27	16	^Citation239
IL4	Interleukin 4	5	^Citation71,Citation227,Citation240	^Citation120,Citation241,Citation242		^Citation5
IL4R	Interleukin 4 receptor	16	^Citation227,Citation243	^Citation79,Citation241
IL5	Interleukin 5 (colony-stimulating factor, eosinophil)	5	^Citation244
IL6	Interleukin 6	7	^Citation118,Citation228,Citation234, ^Citation245^–^Citation247	^Citation116,Citation233, ^Citation236,Citation248		^Citation5,Citation8
IL8	Interleukin 8	4	^Citation120	^Citation234,Citation235,Citation238, ^Citation249,Citation250
IL8RA	Interleukin 8 receptor, alpha	2	^Citation251	^Citation120,Citation146,Citation147
IL8RB (CXCR2)	Interleukin 8 receptor, beta	2	^Citation250	^Citation120,Citation146,Citation147
IL10	Interleukin 10	1	^Citation149,Citation227,Citation235, ^Citation248,Citation252^–^Citation254	^Citation120,Citation234,Citation255
IL12B	Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	5	^Citation227	^Citation239
IL13	Interleukin 13	5	^Citation79,Citation241,Citation242, ^Citation256^–^Citation261	^Citation71,Citation120,Citation238, ^Citation243,Citation262		^Citation5
IL13RA1	Interleukin 13 receptor, alpha 1	X	^Citation241
IL17F	Interleukin 17F	6	^Citation263
IREB2	Iron-responsive element binding protein 2	15	^Citation26,Citation30,Citation47
KCNMB1	Potassium large conductance calcium-activated channel, subfamily M, beta member 1	5	^Citation264
KEAP1	Kelch-like ECH-associated protein 1	19	^Citation265
LEP	Leptin	7	^Citation266
LEPR	Leptin receptor	1	^Citation267
LTA	Lymphotoxin alpha (TNF superfamily, member 1)	6	^Citation234,Citation268^–^Citation272	^Citation120,Citation233,Citation248, ^Citation273^–^Citation275		^Citation5
LTA4H	Leukotriene A4 hydrolase	12	^Citation84
LTBP4	Latent transforming growth factor beta binding protein 4	19	^Citation146,Citation147
MBL2	Mannose-binding lectin (protein C) 2, soluble	10	^Citation276,Citation277
MICB	MHC class I polypeptide-related sequence B	6	^Citation278
MIR196A2	MicroRNA 196a-2	12	^Citation279
MIR499A	MicroRNA 499a	20	^Citation279
MMP1	Matrix metallopeptidase 1 (interstitial collagenase)	11	^Citation146,Citation280,Citation281	^Citation69,Citation128,Citation147, ^Citation151,Citation282^–^Citation285
MMP2	Matrix metallopeptidase 2 (gelatinase A, 72 kDa gelatinase, 72 kDa type IV collagenase)	16	^Citation285	^Citation69,Citation281
MMP3	Matrix metallopeptidase 3 (stromelysin 1, progelatinase)	11	^Citation286	^Citation128,Citation287
MMP9	Matrix metallopeptidase 9 (gelatinase B, 92 kDa gelatinase, 92 kDa type IV collagenase)	20	^Citation128,Citation202,Citation281, ^Citation282,Citation284, ^Citation288^–^Citation290	^Citation69,Citation147,Citation151, ^Citation280,Citation283,Citation285,Citation287		^Citation5,Citation8
MMP12	Matrix metallopeptidase 12 (macrophage elastase)	11	^Citation280,Citation283, ^Citation291,Citation292	^Citation69,Citation146,Citation147, ^Citation282,Citation284, ^Citation285,Citation287
MMP14	Matrix metallopeptidase 14 (membrane-inserted)	14	^Citation293
MSR1	Macrophage scavenger receptor 1	8	^Citation137,Citation294
NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	8	^Citation132
NFE2L2	Nuclear factor (erythroid-derived 2)-like 2	2	^Citation265,Citation295
NFKBIB	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	19	^Citation185
NOS3	Nitric oxide synthase 3 (endothelial cell)	7	^Citation57,Citation62, ^Citation296,Citation297	^Citation149
NQO1	NAD(P)H dehydrogenase, quinone 1	16	^Citation90
NR3C1	Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	5	^Citation298	^Citation299
OGG1	8-oxoguanine DNA glycosylase	3	^Citation300	^Citation189
OR4X1	Olfactory receptor, family 4, subfamily X, member 1	11	^Citation301
PDE4D	Phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, drosophila)	5	^Citation302
PLAUR	Plasminogen activator, urokinase receptor	19	^Citation303,Citation304
PPARG	Peroxisome proliferator-activated receptor gamma	3	^Citation163
PTEN	Phosphatase and tensin homolog	10	^Citation14
PTGDR	Prostaglandin D2 receptor (DP)	14	^Citation305
PTGS2 (COX2)	Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	1	^Citation306,Citation307
SERPINA1	Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	14	^Citation76,Citation308^–^Citation325	^Citation326^–^Citation336
SERPINA3	Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	14	^Citation337^–^Citation343	^Citation146,Citation147,Citation149, ^Citation151,Citation310,Citation314, ^Citation326,Citation332,Citation344		^Citation5
SERPINE2	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2	2	^Citation77,Citation146,Citation149, ^Citation326,Citation345^–^Citation348	^Citation147,Citation152,Citation171, ^Citation349,Citation350
SFTPA1	Surfactant protein A1	10	^Citation69,Citation351
SFTPA2	Surfactant protein A2	10	^Citation69
SFTPB	Surfactant protein B	2	^Citation147,Citation151,Citation171, ^Citation351^–^Citation354	^Citation69,Citation77,Citation146, ^Citation149,Citation152,Citation355
SFTPC	Surfactant protein C	8	^Citation356	^Citation357
SFTPD	Surfactant protein D	10	^Citation69,Citation358,Citation359	^Citation151,Citation351
SIRT2	Sirtuin 2	19	^Citation185
SLC6A4	Solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	17	^Citation360
SLC11A1	Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	2	^Citation361
SMAD3	SMAD family member 3	15	^Citation362
SMOC2	SPARC related modular calcium binding 2	6	^Citation363
SOD2	Superoxide dismutase 2, mitochondrial	6	^Citation364^–^Citation366	^Citation91,Citation92,Citation271		^Citation8
SOD3	Superoxide dismutase 3, extracellular	4	^Citation90,Citation91,Citation364, ^Citation367^–^Citation370		^Citation5	^Citation8
SOX5	SRY (sex determining region Y)-box 5	12	^Citation371
STAT1	Signal transducer and activator of transcription 1, 91 kDa	2	^Citation185
STAT3	Signal transducer and activator of transcription 3 (acute-phase response factor)	17	^Citation372
STAT6	Signal transducer and activator of transcription 6, interleukin-4 induced	12	^Citation79	^Citation241
STIP1	Stress-induced-phosphoprotein 1	11	^Citation373
TBXA2R	Thromboxane A2 receptor	19	^Citation244,Citation374
TGFB1	Transforming growth factor, beta 1	19	^Citation69,Citation77,Citation146, ^Citation147,Citation238, ^Citation375^–^Citation382	^Citation30,Citation149,Citation151, ^Citation171,Citation383	^Citation5,Citation8	^Citation384
TGFBR3	Transforming growth factor, beta receptor III	1	^Citation190
TIMP1	TIMP metallopeptidase inhibitor 1	X	^Citation285	^Citation69
TIMP2	TIMP metallopeptidase inhibitor 2	17	^Citation146,Citation385,Citation386	^Citation147,Citation151,Citation387		^Citation5
TLR4	Toll-like receptor 4	9	^Citation388,Citation389	^Citation96,Citation271
TNF	Tumor necrosis factor (TNF superfamily, member 2)	6	^Citation11,Citation149,Citation151, ^Citation234,Citation238,Citation250, ^Citation262,Citation268, ^Citation270^–^Citation272, ^Citation390^–^Citation398	^Citation83,Citation120,Citation146, ^Citation147,Citation155,Citation230, ^Citation233,Citation235^–^Citation237, ^Citation248,Citation269, ^Citation273^–^Citation275, ^Citation399^–^Citation403	^Citation5,Citation8^–^Citation11
TNS1	Tensin 1	2	^Citation191
TP53 (p53)	Tumor protein p53	17	^Citation101,Citation307
TRPV4	Transient receptor potential cation channel, subfamily V, member 4	12	^Citation404
TSLP	Thymic stromal lymphopoietin	5	^Citation405
VDR	Vitamin D (1,25-dihydroxyvitamin D3) receptor	12	^Citation406^–^Citation408	^Citation409
VEGFA	Vascular endothelial growth factor A	6	^Citation410	^Citation411
XRCC1	X-ray repair complementing defective repair in Chinese hamster cells 1	19	^Citation300
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	2	^Citation412

Figure 1 Candidate genes associated with chronic obstructive pulmonary disease (COPD) or related phenotypes.

Notes: The upper part shows a histogram of the number of COPD susceptibility genes based on the number of publications supporting a significant genetic association. The lower part shows the corresponding genes in each bar. Official gene symbols are indicated. The number of publications that are supportive is indicated in parentheses. References are provided in Table 1 for genes supported by at least one publication and in Supplementary Table 1 for genes tested but not supported.

Figure 2 Scatter plot showing the number of studies supporting and not supporting candidate genes for chronic obstructive pulmonary disease.

Notes: A total of 192 genes are illustrated. Note that many genes overlap in the lower-left corner and the 192 dots cannot be visualized on this display. The gray and red lines are the regression and identity lines, respectively. Genes studied many times or more consistently replicated are illustrated.

Table 2 Susceptibility loci for chronic obstructive pulmonary disease (COPD) and related phenotypes identified by genome-wide association studies

Reference	Study*	Sample size (cases/controls)	Disease/trait	Platform (# SNPs)	Region (size)	Gene	Key SNPs
Pillai et al^Citation15	Norway	823/810	COPD	Illumina (Human Hap550)	15q25	CHRNA3	rs8034191
	ICGN	1891				CHRNA5	rs1051730
	NETT-NAS	389/472
	EOCOPD	949
					4q31	HHIP	rs1828591
							rs13118928
Cho et al^Citation19	Norway	2940/1380	COPD	Illumina (Human Hap550 or Quad610)	4q22	FAM13A	rs7671167
	NETT-NAS						rs1903003
	ECLIPSE
	COPDGene	502/504
	EOCOPD	949
	ICGN	2859
					15q25	CHRNA3	rs1062980
						CHRNA5
						IREB2
					4q31	HHIP	rs1828591
Cho et al^Citation20	ECLIPSE	1764/178	COPD	Illumina (Human Hap550, Quad610, or Omni1 Quad)	19q13	RAB4B	rs7937
	NAS-NETT	373/435				EGLN2	rs2604894
	GenKOLS	863/808				MIA
	COPDGene	499/501				CYP2A6
	ICGN	983 probands/ 1876 siblings
					4q22	FAM13A	rs1964516
							rs7671167
					4q31	HHIP	rs13141641
							rs13118928
					15q25	CHRNA3	rs11858836
						CHRNA5	rs13180
						IREB2
Wilk et al^Citation37	FHS	1059–1222	Ten spirometry phenotypes	Affymetrix (70,987)	10q25	GSTO2	rs156697
Wilk et al^Citation38	FHS	7691	FEV1/FVC	Affymetrix (500 K + 50 K)	4q31	HHIP	rs13147758
	Family heart study	835
Repapi et al^Citation40	SpiroMeta Consortium	20,288	FEV1 and FEV1/FVC	Affymetrix and Illumina (2.5 million)	4q31	HHIP	rs12504628
	CHARGE consortium	32,184
		21,209
	Health 2000 survey	883
			FEV1		2q35	TNS1	rs2571445
					4q24	GSTCD	rs10516526
					5q33	HTR4	rs3995090
			FEV1/FVC		6p21	AGER	rs2070600
					15q23	THSD4	rs12899618
Hancock et al^Citation39	CHARGE Consortium	20,890	FEV1/FVC	Affymetrix and Illumina (2,515,866)	2q36	PID1	rs1435867
	SpiroMeta consortium	16,178
					4q22	FAM13A	rs2869967
					4q31	HHIP	rs1980057
					5q33	HTR4	rs11168048
					5q33	ADAM19	rs2277027
					6p21	AGER-PPT2	rs2070600
					6q24	GPR126	rs3817928
					9q22	PTCH1	rs16909898
			FEV1		4q24	INTS12	rs17331332
						GSTCD
						NPNT
Soler Artigas et al^Citation41,**	23 studies	48,201	FEV1	Illumina and Affymetrix (2,706,349)	3q26	MECOM	rs134555
	17 studies	46,411
					6p22	ZKSCAN3	rs6903823
					10q22	C10orf11	rs11001819
			FEV1/FVC		1p36	MFAP2	rs2284746
					1q41	TGFB2- LYPLAL1	rs993925
					2q37	HDAC4- FLJ43879	rs12477314
					3p24	RARB	rs1529672
					5q15	SPATA9- RHOBTB3	rs153916
					6q21	ARMC2	rs2798641
					6p21	NCR3-AIF1	rs2857595
					12q13	LRP1	rs11172113
					12q22	CCDC38	rs1036429
					16q13	MMP15	rs12447804
					16q23	CFDP1	rs2865531
					21q22	KCNE2- LINC00310	rs9978142
			FEV1 and FEV1/FVC		10p23	CDC123	rs7068966
Imboden et al^Citation42	SAPALDIA	2677 nonasthmatic, 1441 asthmatic	FEV1 decline in nonasthmatic	Illumina	13q14	DLEU7	rs9316500
	ECRHS			Human
	EGEA			610quad
	FHS	10,858 nonasthmatic, 1138 asthmatic
	ARIC
	B58C
	Dutch asthma study
			FEV1/FVC decline in asthmatic		8p22	TUSC3	rs4831760
Kong et al^Citation43	ECLIPSE	1557	Emphysema (qualitative)	Illumina	12q11	BICD1	rs10844154
	Norway	432		Human			rs161976
				Hap550 (499,578)
Wan et al^Citation44	ECLIPSE	1734	Cachexia-related phenotypes (BMI and fat-free mass index)	Illumina	16q12	FTO	rs8050136
	Norway	851
	NETT	365
	COPDGene	502

Notes:

* Bold entries indicates replication cohorts;

** only the new loci are identified for this study, but ten loci previously reported by Hancock et al³⁹ and Repapi et al⁴⁰ were also detected.

Abbreviations: ARIC, Atherosclerosis Risk in Communities; B58C, British 1958 Birth Cohort; EOCOPD, Boston Early-Onset COPD Study; BMI, body mass index; COPDGene, COPDGene study; ECLIPSE, Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints; ECRHS, European Community Respiratory Health Survey; EGEA, Epidemiological study on the Genetics and Environment of Asthma; FEV₁, forced expiratory volume in 1 second; FHS, Framingham Heart Study; FVC, forced vital capacity; GenKOLS, Bergen, Norway COPD Cohort; ICGN, International COPD Genetics Network study; NAS-NETT, Normative Aging Study and National Emphysema Treatment Trial; SAPALDIA, Swiss Cohort Study on Air Pollution and Lung and Heart Disease in Adults; SNPs, single-nucleotide polymorphisms.

Table S1 Genes tested but showing lack of association with chronic obstructive pulmonary disease

Symbol	Name	Chromosome	References
			Single studies		Meta-analyses
			Positive	Negative	Positive	Negative
AGER	Advanced glycosylation end product-specific receptor	6	^Citation1,Citation2
CASP8	Caspase 8, apoptosis-related cysteine peptidase	2	^Citation3
CCL17 (TARC)	Chemokine (C-C motif) ligand 17	16	^Citation4
CCL2	Chemokine (C-C motif) ligand 2	17	^Citation5
CFLAR	CASP8 and FADD-like apoptosis regulator	2	^Citation3
COL6A5	Collagen, type VI, alpha 5	3	^Citation6
CXADR	Coxsackie virus and adenovirus receptor	21	^Citation7
CYP1B1	Cytochrome P450, family 1, subfamily B, polypeptide 1	2	^Citation8,Citation9
CYP2D6	Cytochrome P450, family 2, subfamily D, polypeptide 6	22	^Citation10
DCN	Decorin	12	^Citation11
DNAJB1	DnaJ (Hsp40) homolog, subfamily B, member 1	19	^Citation12
EDNRA	Endothelin receptor type A	4	^Citation13
FGA	Fibrinogen alpha chain	4	^Citation14
FGB	Fibrinogen beta chain	4	^Citation14,Citation15
FGG	Fibrinogen gamma chain	4	^Citation14
FKBP4	FK506 binding protein 4, 59 kDa	12	^Citation12
FKBP5	FK506 binding protein 5	6	^Citation12
FLCN	Folliculin	17	^Citation16
GABPA	GA binding protein transcription factor, alpha subunit 60 kDa	21	^Citation17
GPX1	Glutathione peroxidase 1	3	^Citation18,Citation19
GSTM3	Glutathione S-transferase mu 3 (brain)	1	^Citation20
HDAC2	Histone deacetylase 2	6	^Citation1
HDAC5	Histone deacetylase 5	17	^Citation1
HSP90AA1 (HSPCA)	Heat shock protein 90 kDa alpha (cytosolic), class A member 1	14	^Citation12
HSP90AB1 (HSPCB)	Heat shock protein 90 kDa alpha (cytosolic), class B member 1	6	^Citation12
HSPA1A	Heat shock 70 kDa protein 1A	6	^Citation21
HSPA1B	Heat shock 70 kDa protein 1B	6	^Citation21
HSPA1L	Heat shock 70 kDa protein 1-like	6	^Citation21
HSPA8	Heat shock 70 kDa protein 8	11	^Citation12
IL11	Interleukin 11	19	^Citation1
IL13RA2	Interleukin 13 receptor, alpha 2	X	^Citation22
ITGB5	Integrin, beta 5	3	^Citation7
JAK3	Janus kinase 3	19	^Citation1
KCND2	Potassium voltage-gated channel, Shal-related subfamily, member 2	7	^Citation1
MAP3K5	Mitogen-activated protein kinase kinase kinase 5	6	^Citation1
MIR146a	MicroRNA 146a	5	^Citation23
MRPL44	Mitochondrial ribosomal protein L44	2	^Citation24
ORMDL3	ORM1-like 3 (S cerevisiae)	17	^Citation25
PTGES3	Prostaglandin E synthase 3 (cytosolic)	12	^Citation12
RARRES2	Retinoic acid receptor responder (tazarotene induced) 2	7	^Citation1
SCGB1A1 (CC16)	Secretoglobin, family 1A, member 1 (uteroglobin)	11	^Citation26
SOD1	Superoxide dismutase 1, soluble	21	^Citation18,Citation27
TBX21	T-box 21	17	^Citation28
THSD4	Thrombospondin, type I, domain containing 4	15	^Citation2
TLR2	Toll-like receptor 2	4	^Citation29,Citation30
TLR6	Toll-like receptor 6	4	^Citation31
TNFRSF1A	Tumor necrosis factor receptor superfamily, member 1A	12	^Citation32
TNFRSF1B	Tumor necrosis factor receptor superfamily, member 1B	1	^Citation32

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