Czech multicenter research database of severe COPD

Figures & data

Figure 1 The time schedule of the Czech Multicentre Research Database of Severe COPD.

Note: The prospective follow-up period can be extended, if necessary, due to statistical analysis of all-cause mortality.
Abbreviation: COPD, chronic obstructive pulmonary disease.

Figure 2 The twelve participating centers in the Czech Republic.

Table 1 Data collection scheme

Appointment type	Baseline appointment (stable COPD)	Planned appointment (stable COPD)	Emergency appointment (with or without hospitalization)	End of study
Appointment interval	Registry enrollment	Every 6 months	In the event of emergency hospitalization (ie, not planned hospitalization)
Appointment number	1	2–11	E1, E2, E3 …
✓Informed consent	X
✓Patient history	X	X
✓Demographic data	X
Risk factors	X	X
✓Symptoms (mMRC, CAT***)	X	X
Quality of life (SGRQ)	X	X
✓Current medications	X	X
✓Physical examination	X	X
ECG	X	X*
Laboratory test (A1AT)	X
✓Frequency of exacerbations	X	X*
✓Nasal symptoms (SNOT-22)***	X	X*
✓Lung function	X	X
Arterial blood gases	X	X
✓6MWT***	X	X
Pedometer (ADL°)	X	X*
Depression questionnaires	X	X
Chest HRCT	X	X§
Echocardiography	X	X**
DEXA	X
Skinfold anthropometry	X	X*
Compliance assessment	X	X*
Blood sample (−70°C) – genomic analysis	X
Reason for sudden hospital admission			X
Patient progress during admission			X
Patient self-withdrawal from study				X
✓Cause of death				X
5-year survival				X

Notes:

✓ Mandatory.

* Once a year.

** During the third and fifth year of study.

° Monthly average.

§ During the fifth year of study.

*** Mandatory, but with the option “unable to perform”.

Abbreviations: 6MWT, 6-minute walking test; A1AT, α1-antitrypsin; ADL, activity of daily living; CAT, COPD Assessment Test; COPD, chronic obstructive pulmonary disease; DEXA, dual energy X-ray absorptiometry; E1–E3, emergency appointment 1–3; ECG, electrocardiography; HRCT, high-resolution computer tomography; mMRC, modified Medical Research Council dyspnea scale; SGRQ, St George’s Respiratory Questionnaire; SNOT-22, Sino-Nasal Outcome Test.

Table 2 Tracked comorbidities and their treatment

Comorbidities	Treatment
Bronchial asthma in the personal history
Bronchial asthma currently
Coronary artery disease (stable angina)	Pharmacotherapy involving statins
Coronary artery disease (ST elevation myocardial infarction)	Angioplasty
Coronary artery disease (non-ST elevation myocardial infarction)	Surgery
Heart failure	Diuretics
	β-blockers
	Angiotensin-converting enzyme inhibitors
Atrial fibrillation	Pharmacotherapy
	Electroversion
Arterial hypertension	Pharmacotherapy
Arrhythmia and/or syncope and/or palpitation	Pacemaker
	Implantable cardioverter defibrillator
Malignancy
Osteoporosis
Diabetes
Anemia
Depression
Peptic ulcer
Sleep apnea syndrome	Noninvasive ventilator support

Table 3 Definitions of clinical phenotypes used in this study

Clinical phenotype	Simplified specification	Notes
Chronic bronchitis phenotype	The patient answers yes to both questions about chronic presence of cough and expectoration
Emphysematous phenotype	Radiology specialist says yes to the assessment of pulmonary emphysema by chest HRCT
COPD with bronchiectasis	Defined by presence of bronchiectasis (in two or more lobes) on a chest HRCT	Chronic presence of cough and expectoration is not required
Asthma–COPD overlap syndrome	Definite COPD subjects met two or more major or one major plus two minor criteria^Citation10,Citation12	Major: strong bronchodilator test positivity (FEV1 >15% and >400 mL), bronchial challenge test positivity, FeNO ≥45–50 ppb and/or sputum eosinophils ≥3%, history of asthma Minor: mild bronchodilator test positivity (FEV1 >12% and >200 mL), ↑ total immunoglobulin E, history of atopy
Frequent exacerbation phenotype	Two or more acute exacerbations per year
Pulmonary cachexia phenotype	BMI <21 kg/m^2 in absence of another valid reason

Abbreviations: BMI, body mass index; COPD, chronic obstructive pulmonary disease; FeNO, fractional exhaled nitric oxide; FEV₁, forced expiratory volume in 1 second; HRCT, high-resolution computed tomography.

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