POPE study: rationale and methodology of a study to phenotype patients with COPD in Central and Eastern Europe

Figures & data

Table 1 POPE study – participating centers

Austria
National expert	Assoc Prof Arschang Valipour, MD, PhD
	Ludwig Boltzmann Institute, Wien
	AKH Linz, Department of Pulmonary Medicine
	Pulmonary Rehab Centre, Therme Wien
	Department of Internal Medicine, University Innsbruck
	SKA der PV Weyer/Enns, Mühlein
Bulgaria
National expert	Assoc Prof Kosta Kostov, MD, PhD
	Pulmonary Diseases Clinic, Military Medical Academy, Sofia
	Clinic for Pneumonology and Phisiatry, UMHAT “Dr Georgi Stranski”, Pleven
	Clinic of Pulmonology, MHAT “St Marina”, Varna
	Department of Respiratory Diseases, Medical University, Plovdiv
Croatia
National expert	Prof Neven Tudoric, MD, PhD
	University Hospital Dubrava, Zagreb
	University Hospital Centre, Zagreb
	University Hospital Centre, Split
	University Hospital Centre, Rijeka
	Clinical Hospital, Osijek
Czech Republic
National expert	Vladimir Koblizek, MD, PhD
	Outpatient Department of Pneumology and Pulmonary Diagnostics, Karlovy Vary
	Pneumological Outpatient Department, Mepha-Centrum, Ostrava
	Pneumology Centre, Teplice
	Department of Pneumology, University Hospital Hradec Králové and Faculty of Medicine in Hradec Králové of the Charles
	University in Prague
Hungary
National expert	Prof Attila Somfay, MD, PhD
	Csongrád County Hospital for Chest Diseases, Deszk
	IZO PULM Health Service Ltd., Budapest
	St Elizabeth Hospital Pulmonary Care Institute, Jászberény
	Szarvas Respiratory Ltd., Szarvas
	Újpest Non-Profit Health Care Services Ltd., Budapest
	Elizabeth House Care Ltd., Gödöllő
	Medical Institution of Dr Laszlo Romics Pulmonary Care, Érd
	Szabolcs-Szatmár-Bereg County Hospitals and University Teaching Hospital, Nyíregyháza
	Baja St Rókus Hospital Patient Lung Care Institute, Baja
Latvia
National expert	Prof Alvis Krams, MD, PhD
	Regional Hospital of Liepaja
	Kuldīga Hospital
	SIA “BINI”, Ventspils
	Health Centre Talsi
	Ambulatory Clinic Jelgava
	Bauska Hospital
	Ambulatory Clinic Dubulti, Jurmala
	Privat practice Ilona Uzbeka, Valka
	Privat practice Dace Harasimjuka, Valmiera
	Madona Hospital
	Health Centre Balvi
	Private practice Viktorija Vevere, Rezekne
	Regional Hospital of Jekabpils
	Pauls Stradins Clinical University Hospital, Riga
	Riga East Clinical University Hospital, “Gailezers”, Riga
	Riga East Clinical University Hospital, In-patient Department “Centre of Tuberculosis and Lung Diseases”, Riga
	LU MPI Institute private practice, Riga
	Riga 1st Hospital, Riga
	Health Centre 4, Ltd, Riga
	UniClinic, Riga
Poland
National expert	Assoc Prof Adam Barczyk, MD, PhD
	Oddział Chorób Płuc i Niewydolności Oddychania, Kujawsko – Pomorskie, Centrum Pulmonologii w Bydgoszczy, Bydgoszcz
	Katedra i Klinika Chorób Wewnętrznych, Pneumonologii i Alergologii, Samodzielny Publiczny Centralny Szpital Kliniczny, Warszawa
	Klinika Alergologii i Pneumonologii, Uniwersyteckie Centrum Kliniczne, Szpital Gdańskiego Uniwersytetu Medycznego, Gdańsk
	Oddział Chorób Płuc, Wojewódzkie Centrum Szpitalne Kotliny Jeleniogórskiej, Jelenia Góra
	Katedra i Klinika Pulmonologii, Alergologii i Onkologii Pulmonologicznej, Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Poznań
	Szpital Uniwersytecki, Oddział Kliniczny Kliniki Pulmonologii, Kraków
	Katedra i Klinika Pneumonologii, Śląski Uniwersytet Medyczny, Katowice
Russia
National expert	Prof Kirill Zykov, MD, PhD
	Pulmonology Research Institute, Moscow
	Ufa State City Clinical Hospital 21, Ufa
	Clinic of Pulmonology of Scientific and Clinical Center of Interstitial and Orphan Lung Diseases, St Petersburg
	State Budget Educational Institution of High Professional Education “Kazan State Medical University”, Kazan
	Vladivostok Clinical Hospital #1, Vladivostok
	I.M. Sechenov First Moscow State Medical University, University Hospital #1, Outpatient Department, Moscow
	GBOU VPO Samara State Medical University, Samara
	Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow
Serbia
National expert	Prof Branislava Milenkovic, MD, PhD
	Clinic for Pulmonary Diseases, Clinical Centre of Serbia, Belgrade
	Institute for Pulmonary Diseases and TB, Clinical Centre Vojvodina, Novi Sad
	Clinic for Pulmonary Diseases, Clinical Center of Niš
	Clinic for Pulmonary Diseases, Clinical Centre Kragujevac
	Municipal Institute for Lung Diseases and Tuberculosis, Belgrade
Slovakia
National expert	Prof Ruzena Tkacova, MD, PhD
	Ambulancia pneumológie a ftizeológie Doc. MUDr Ján Plutinský, CSc, Levice
	Pľúcna ambulancia, Poprad
	MUDr Katarína Arpášová – Dionea, s.r.o., Nové Zámky
	Klinika pneumológie a ftizeológie LF SZU a UNB, Bratislava
	NsP, Považská Bystrica
	Zdravotné stredisko Fedinova, Bratislava
	Klinika tubekulózy a respiračných chorôb JLF UK a UNM, Martin
	FNsP F.D. Roosevelta, Banská Bystrica
	NsP Sv. Jakuba, Bardejov
	Zdravotné stredisko Rimava, Rimavská Sobota
Slovenia
National expert	Jurij Šorli, MD, PhD
	Bolnišnica Topolšica, Topolšica
	Alveola, d.o.o., Maribor
	Zdravstveni dom Murska Sobota, Murska Sobota

Table 2 POPE study – Steering Committee

Steering Committee members
Austria	Assoc Prof Arschang Valipour, MD, PhD
Croatia	Prof Neven Tudoric, MD, PhD
Czech Republic	Vladimir Koblizek, MD, PhD
Hungary	Prof Attila Somfay, MD, PhD
Poland	Assoc Prof Adam Barczyk, MD, PhD
Russia	Prof Kirill Zykov, MD, PhD
Slovakia	Prof Ruzena Tkacova, MD, PhD
Spain	Prof Marc Miravitlles, MD, PhD

Figure 1 Map of participating countries.

Figure 2 Definition of phenotypes.

Abbreviations: ACOS, asthma–COPD overlap syndrome; BD, bronchodilator; CB, chronic bronchitis.

Table 3 POPE study – captured parameters

Form	Parameter
History	Demographic data
	Age of first diagnosis
	History of allergy/atopy
	COPD symptoms
	Smoking history
	Other than tobacco smoking risk factorsa
	History of acute respiratory events
	Concomitant respiratory diseases
	Weight assessment
	Comorbidities – Charlson comorbidity index
	Comorbidities – others
Physical examination	BMI
	Heart and breath frequency
	Physical signs of COPD and heart failure sings
Pulmonary function	Postbronchodilator spirometry values
	Body plethysmography (TLC and RV)b
	TLCO and KCOb
	Bronchodilator testb
	Bronchial challenge testb
	FeNOb
	HRCT of thoraxb
	Echocardiographyb
	Blood/sputum eosinophil assessmentb
	6-minute walk testb
	Total serum IgE measurementb
	ABGb
	HCTb
Questionnaires	CAT (total score and all 8 items separately)
	mMRC
Treatment	COPD pharmacological and nonpharmacological treatment
	Other respiratory treatment
	LTOT
	Surgery and BVR
	Vaccination
	Nonrespiratory concomitant treatment

Notes:

a Required in nonsmokers,

b optional.

Abbreviations: ABG, arterial blood gas; BMI, body mass index; BVR, bronchoscopic lung volume reduction; CAT, the COPD assessment test; COPD, chronic obstructive pulmonary disease; FeNO, fractional exhaled nitric oxide; HCT, hematocrit; HRCT, high-resolution computed tomography; IgE, immunoglobulin E; K_CO, Krogh factor; LTOT, long-term oxygen therapy; mMRC, modified Medical Research Council dyspnea scale; RV, residual volume; TLC, total lung capacity; TL_CO, transfer factor.

Table 4 POPE study – distribution of COPD patients between general practitioners and pulmonologists in CEE

Country	Pope study cohorta		General approach in countryb
	Pulmonologists (%)	GPs (%)	Pulmonologists (%)	GPs (%)
Austria	100	0	60	40
Bulgaria	100	0	50	50
Croatia	100	0	50	50
Czech Republic	100	0	95	5
Hungary	100	0	100	0
Latvia	100	0	NA	NA
Poland	100	0	50	50
Russia	100	0	50	50
Serbia	100	0	100	0
Slovakia	100	0	100	0
Slovenia	100	0	NA	NA
Spain	Nonparticipant		25	75

Notes:

a Clear data,

b approximation by Steering Committee members.

Abbreviations: CEE, Central and Eastern Europe; GPs, general practitioners; NA, nonavailable.