Safety and efficacy of Becaplermin gel in the treatment of diabetic foot ulcers

Figures & data

Table 1 Efficacy of Becaplermin

Study	Study size (number of patients)	Percent healed (Becaplermin)	Percent healed (control)	Trial design
Wieman et al^Citation9	382	50% of patients treated with Becaplermin gel 100 μg 36% of patients treated with Becaplermin gel 30 μg	35% of patients treated with the placebo	Double-blinded, placebo-controlled
Embil et al^Citation11	134	57.5% had complete healing 23% had marked improvement of 51%–99% closure	No control	Phase IIIB open-label
Margolis et al^Citation12	2,394	33.5% treated with Becaplermin gel	25.8% of patients who were treated with another agent	Cohort study
Smiell et al^Citation10	922	50% of patients treated with Becaplermin 100 μg gel 42% of patients treated with Becaplermin 30 μg gel	36% of patients treated with the placebo gel 36% of patients treated with wound care alone	Meta-analysis

Figure 1 Reported adverse drug events with use of Becaplermin gel.

Wieman TJ, Smiell JM, Su Y. Efficacy and safety of a topical gel formulation of recombinant human platelet-derived growth factor-BB (becaplermin) in patients with chronic neuropathic diabetic ulcers. A phase III randomized placebo-controlled double-blind study. Diabetes Care. 1998;21(5):822–827.

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Embil JM, Papp K, Sibbald G, et al. Recombinant human platelet-derived growth factor-BB (becaplermin) for healing chronic lower extremity diabetic ulcers: an open-label clinical evaluation of efficacy. Wound Repair Regen. 2000;8(3):162–168.

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Margolis DJ, Bartus C, Hoffstad O, Malay S, Berlin JA. Effectiveness of recombinant human platelet-derived growth factor for the treatment of diabetic neuropathic foot ulcers. Wound Repair Regen. 2005;13(6):531–536.

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Smiell JM, Wieman TJ, Steed DL, Perry BH, Sampson AR, Schwab BH. Efficacy and safety of becaplermin (recombinant human platelet-derived growth factor-BB) in patients with nonhealing, lower extremity diabetic ulcers: a combined analysis of four randomized studies. Wound Repair Regen. 1999;7(5):335–346.

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