Figures & data
Table 1 Review and comparison of ixazomib, bortezomib, and carfilzomib
Figure 1 Mechanism of action of ixazomib.
Notes: Ixazomib (MLN9708) administered orally as a capsule is rapidly absorbed and hydrolyzed to the biologically active form (MLN2238) when it comes in contact with aqueous plasma. Ixazomib blocks protein degradation by inhibiting the 20S catalytic subunit of the 26S proteasome. More specifically, at lower concentrations, MLN2238 inhibits the β5 chymotrypsin-like subunit, which cleaves proteins after hydrophobic residues. At high concentrations, MLN2238 inhibits the β1 caspase-like subunit and β2 trypsin-like subunit, which cleave proteins after acidic and basic residues, respectively.
Table 2 Summary of completed and ongoing clinical trials of ixazomib in MM