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Diabetes, Metabolic Syndrome and Obesity Volume 9, 2016 - Issue
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Original Research

Effects of vildagliptin relative to sulfonylureas in Muslim patients with type 2 diabetes fasting during Ramadan: influence of age and treatment with/without metformin in the VIRTUE study

Ahmed AK Hassoun1 Dubai Diabetes Centre, Dubai, UAECorrespondence[email protected]
,
Md Faruque Pathan2 Department of Endocrinology, BIRDEM Hospital, Dhaka, Bangladesh
,
Rita C Medlej3 Department of Endocrinology, Hotel Dieu de France Hospital;4 Chronic Care Centre, Saint Joseph University, Beirut, Lebanon
,
Monira Alarouj5 Dasman Diabetes Institute, Dasman, Kuwait
,
Inass Shaltout6 Faculty of Medicine, Cairo University, Cairo, Egypt
,
Manoj S Chawla7 Lina Diabetes Care Centre, Mumbai, India
,
Ditte Knap8 Novartis Pharma AG, Basel, Switzerland
&
Julius A Vaz9 Novartis Healthcare Private Limited, Hyderabad, India
 show all
Pages 225-231 | Published online: 26 Jul 2016

Figures & data

Table 1 Patient demographics and baseline characteristics by therapy type and age (safety set)

Figure 1 Number of patients in the vildagliptin and SU treatment cohorts with one or more HEs during Ramadan fasting according to (A) therapy type (monotherapy or dual therapy with metformin) and (B) age (<65 years or ≥65 years; primary analysis set).

Note: *P<0.001 vs SU cohort (Fisher’s exact test).
Abbreviations: SU, sulfonylurea; HEs, hypoglycemic events.
Figure 1 Number of patients in the vildagliptin and SU treatment cohorts with one or more HEs during Ramadan fasting according to (A) therapy type (monotherapy or dual therapy with metformin) and (B) age (<65 years or ≥65 years; primary analysis set).

Figure 2 Mean (SD) change in HbA1c from prefasting baseline to study end for patients in vildagliptin and SU treatment cohorts.

Notes: (A) Therapy type (monotherapy or dual therapy with metformin) and (B) age (<65 years or ≥65 years).
Abbreviations: HbA1c, glycated hemoglobin; SU, sulfonylurea; SD, standard deviation.
Figure 2 Mean (SD) change in HbA1c from prefasting baseline to study end for patients in vildagliptin and SU treatment cohorts.
 

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