Novel Anti-obesity Therapies and their Different Effects and Safety Profiles: A Critical Overview

Figures & data

Table 1 Obesity Treatment Options Approved by the Food and Drug Administration (FDA)

Name	Mechanism of Action	Route of Administration	Recommended Dose	Expected Weight Loss, kg
Liraglutide	GLP-1 agonist	Subcutaneous	3 mg once a day	5.7–8
Semaglutide	GLP-1 agonist	Subcutaneous	2.4 mg once a week	9.7–15.3
Tirzepatide*	GLP-1/GIP agonist	Subcutaneous	15 mg once a week	9.5–23.6
Orlistat	Lipase inhibitor	Oral	120 mg three times a day	5.8–10.6
Phentermine-Topiramate	Sympathomimetic amine anorectic/antiepileptic combination	Oral	7.5 mg/46 mg once a day	9.2–12.4
Bupropion-naltrexone	Opioid antagonist/antidepressant combination	Oral	16 mg/180 mg twice a day	3.6–9.3

Note: *Tirzepatide is still under evaluation by the FDA for obesIty treatment approval.

Abbreviations: GLP-1, glucagon-like peptide-1; GIP, glucose-dependent insulinotropic polypeptide.