Factors affecting high-sensitivity cardiac troponin T elevation in Japanese metabolic syndrome patients

Figures & data

Table 1 Patient characteristics

	All	hs-cTnT nondetection	hs-cTnT detection
N	258	32	226
Age (years)	63±11	56±7	64±11*
Smoking (%)	77 (30)	7 (22)	70 (31)
Body mass index (Kg/m^2)	24.7±3.0	24.0±3.0	24.8±3.0
Diagnostic parameters of Mets
Waist circumference (cm)	89±5	89±4	89±5
Triglyceride (mg/dL)	203±60	193±55	204±61
HDL cholesterol (mg/dL)	44±14	43±10	44±15
Systolic BP (mmHg)	141±20	141±18	141±21
Diastolic BP (mmHg)	89±14	87±13	89±14
Fasting blood glucose (mg/dL)	111±15	110±16	111±15
Immunoreactive insulin (μg/mL)	9.6±4.2	9.8±3.4	9.6±4.3
Log-HOMA-IR	0.4±0.3	0.4±0.2	0.4±0.3
Total cholesterol (mg/dL)	226±43	230±44	225±42
LDL cholesterol (mg/dL)	141±40	149±40	140±40
Log-hs-CRP (mg/L)	−1.1±0.4	−1.3±0.6	−51.0±0.4**
d-ROMs test (U Carr)	321±77	266±46	329±77*
Log-BNP (pg/mL)	1.5±0.5	1.2±0.3	1.5±0.5***
eGFR (mL/min/1.73 m^2)	60±21	75±17	58±21*
Cardio-ankle vascular index	9.1±1.5	8.1±1.1	9.2±2.1*
Log-hs-cTnT (ng/mL)	−2.1±0.2	–	−2.1±0.2

Note: Data are expressed mean ± SD.

* P<0.001;

** P<0.05;

*** P<0.01.

Abbreviations: Mets, metabolic syndrome; hs-cTnT, high-sensitivity cardiac troponin T; BP, blood pressure; HOMA-IR, homeostatic model assessment of insulin resistance; LDL, low-density lipoprotein; HDL, high-density lipoprotein; hs-CRP, high sensitivity C-reactive protein; d-ROMs, derivatives of reactive oxygen metabolites; BNP, brain natriuretic peptide; eGFR, estimated glomerular filtration rate.

Table 2 Correlation between hs-cTnT and various clinical parameters in hs-cTnT detectable patients

	r	P value
Age	0.35	<0.01
Smoking (No =0, Yes =1)	0.06	0.39
Body mass index	0.11	0.10
Waist circumference	0.09	0.20
Triglyceride	−0.21	0.06
HDL cholesterol	0.11	0.32
Systolic BP	−0.07	0.57
Diastolic BP	0.02	0.86
Fasting blood glucose	−0.02	0.89
Immunoreactive insulin	−0.10	0.37
Log-HOMA-IR	−0.11	0.30
Total cholesterol	−0.11	0.34
LDL cholesterol	−0.07	0.56
Log-hs-CRP	0.18	<0.01
d-ROMs test	0.43	<0.001
Log-BNP	0.32	<0.01
eGFR	−0.24	<0.05
Cardio-ankle vascular index	0.36	<0.01

Note: (n=226).

Abbreviations: hs-cTnT, high-sensitivity cardiac troponin T; BP, blood pressure; HOMA-IR, homeostatic model assessment of insulin resistance; LDL, low-density lipoprotein; HDL, high-density lipoprotein; hs-CRP, high sensitivity C-reactive protein; d-ROMs, derivatives of reactive oxygen metabolites; BNP, brain natriuretic peptide; eGFR, estimated glomerular filtration rate.

Table 3 Multiple regression analysis for hs-cTnT

	Standard correlation coefficient	t value	P value
Explanatory factor
d-ROMs test	0.37	5.7	<0.001
Log-BNP	0.16	2.6	<0.01
CAVI	0.13	2.2	<0.05
Age	0.11	2.0	<0.05
eGFR	−0.10	−1.4	0.16
Log-hs-CRP	0.06	0.8	0.40

Note:R²=0.28, F value =16.2, P<0.001.

Abbreviations: hs-cTnT, high-sensitivity cardiac troponin T; hs-CRP, high sensitivity C-reactive protein; d-ROMs, derivatives of reactive oxygen metabolites; BNP, brain natriuretic peptide; eGFR, estimated glomerular filtration rate; CAVI, cardio–ankle vascular index.