Evidence for improvements to risk stratification in high-risk gastrointestinal stromal tumor patients

Figures & data

Figure 1 NIH classification.

Note: Adapted from Hum Pathol, 33(5), Fletcher CD, Berman JJ, Corless C, et al, Diagnosis of gastrointestinal stromal tumors: A consensus approach, 459–465, Copyright 2002, with permission from Elsevier.²⁰
Abbreviations: HPF, high power field; NIH, National Institute of Health.

Figure 2 Modified NIH classification.

Notes: Adapted from Hum Pathol, 39, Joensuu, Risk stratification of patients diagnosed with gastrointestinal stromal tumor, 1411–1419, Copyright 2008, with permission from Elsevier.³
Abbreviations: HPF, high power field; NIH, National Institute of Health.

Figure 3 MSKCC prognostic nomogram.

Note: Adapted from Lancet Oncol, 10(11), Gold JS, Gönen M, Gutiérrez A, et al, Development and validation of a prognostic nomogram for recurrence-free survival after complete surgical resection of localised primary gastrointestinal stromal tumour: a retrospective analysis, 1045–1052, Copyright 2009, with permission from Elsevier.²¹
Abbreviations: EUS, endoscopic ultrasonography; EUS-FNA, EUS-guided fine-needle aspiration; GIST, gastrointestinal stromal tumor; SMT, submucosal tumor.

Figure 4 TNM classification for GIST. Adapted from Agaimy A., Gastrointestinal stromal tumor (GIST) from risk stratification systems to the new TNM proposal: more questions than answers? A review emphasizing the need for a standardized GIST reporting. Int J Clin Exp Pathol. 2010;3(5):461–471.⁶⁷

Abbreviations: GIST, gastrointestinal stromal tumor; HPF, high power field; UICC, Union for International Cancer Control.

Table 1 Biological markers

Markers	Prognosis
PDL1	+
Pfetin	+
SETD2	−
SLITRK3	−
miR-215–5 p	+/−^*
MGLL	−

Note:

* Prognostic significance is still controversial.

Abbreviations: +, favorable prognosis; −, poor prognosis; MGLL, monoglyceride lipase; PDL1, programmed cell death ligand 1.

Figure 5 Small GIST treatment.

Note: Adapted from Nishida T et al, Diagnostic and treatment strategy for small gastrointestinal stromal tumors, Cancer, 2016,122(20), 3110–3118.⁶³
Abbreviations: EUS, endoscopic ultrasonography; EUS-FNA, EUS-guided fine-needle aspiration; GIST, gastrointestinal stromal tumor; SMT, submucosal tumor.

Fletcher CD, Berman JJ, Corless C, et al. Diagnosis of gastrointestinal stromal tumors: A consensus approach. Hum Pathol. 2002;33(5):459–465.

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Joensuu H. Risk stratification of patients diagnosed with gastrointestinal stromal tumor. Hum Pathol. 2008;39:1411–1419.

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Gold JS, Gönen M, Gutiérrez A, et al. Development and validation of a prognostic nomogram for recurrence-free survival after complete surgical resection of localised primary gastrointestinal stromal tumour: a retrospective analysis. Lancet Oncol. 2009;10(11):1045–1052.

 PubMed Web of Science ®Google Scholar

Agaimy A. Gastrointestinal stromal tumor (GIST) from risk stratification systems to the new TNM proposal: more questions than answers? A review emphasizing the need for a standardized GIST reporting. Int J Clin Exp Pathol. 2010;3(5):461–471.

 PubMed Web of Science ®Google Scholar

Nishida T, Goto O, Raut CP, Yahagi N. Diagnostic and treatment strategy for small gastrointestinal stromal tumors. Cancer. 2016;122(20):3110–3118.

 PubMed Web of Science ®Google Scholar