Altered levels of cytokines in patients with irritable bowel syndrome are not correlated with fatigue

Figures & data

Table 1 Demographic and clinical data in the patient cohort

Characteristics
Patients, total number	38
Females	84.2% (n=32)
Males	15.8% (n=6)
Age (years), mean (range)	34.7 (18–70)
Duration of symptoms (years), mean (range)	8.2 (1–30)
Atopic sensitized	50% (n=19)
IBS-SSS, mean (range)	288.8 (70–440)
≥300 (severe)	39.5% (n=15)
175–300 (moderate)	52.6% (n=20)
75–<175 (mild)	5.3% (n=2)
<75 (no IBS)	2.6% (n=1)
IBS subgroups
Predominant diarrhea	34.2% (n=13)
Predominant constipation	21.1% (n=8)
Mixed constipation/diarrhea	44.7% (n=17)
Fatigue
Mean FIS (range)	69.8 (9–157)
FIS ≥25	84.2% (n=32)

Abbreviations: FIS, Fatigue Impact Scale; IBS, irritable bowel syndrome; IBS-SSS, IBS-severity scoring system.

Figure 1 The serum levels of cytokines IL-5 (A), IL-6 (B), IL-10 (C), and TNF-α (D) in patients with irritable bowel syndrome and controls.

Abbreviations: IL, interleukin; TNF, tumor necrosis factor.

Figure 2 The serum levels of cytokine IL-1β in patients with irritable bowel syndrome and controls.

Abbreviation: IL, interleukin.

Figure 3 The correlation between IBS-SSS and FIS scores in patients with irritable bowel syndrome (nonsignificant; r=0.2, p=0.19).

Abbreviations: FIS, Fatigue Impact Scale; IBS-SSS, Irritable Bowel Syndrome-Severity Scoring System.