The Association of UCP2-866 G/A Genotype with Autoimmune Hypothyroidism in the Southwestern Saudi Arabia Population

Figures & data

Table 1 Baseline Characteristics of the Control and Hypothyroidism Subjects

Variables		Control (91)	Hypothyroidism (67)	P-value
Gender	Male	25 (100%)	0 (0.0%)	0.000*
	Female	26 (28.0%)	67 (72.0%)
Age		27.82 ± 5.759	36.93 ± 14.656	0.000*
Weight		71.62 ± 13.481	70.59 ± 25.765	0.747
Height(cm)		1.6805 ± 0.06636	1.3616 ± 0.50993	0.000*
BMI		25.3111 ± 4.28554	28.1379 ± 15.67355	0.103

Notes: Data are mean ± SD or percentages. *Highly Significant.

Table 2 The Expected Frequencies of UCP2-868 G/A Consistency with Hardy–Weinberg Equilibrium (HWE)

Genotype	Observed	Expected	ᵡ^2 (P-value)
A/A	21	22	0.2316 (0.8907)
G/A	77	74
G/G	60	62

Notes: ᵡ²–test with 2 degrees of freedom (If P<0.05 – not consistent with HWE).

Table 3 Genotype and Allele Distribution of the UCP2-868 G/A Polymorphism Among Hypothyroid Patients and Healthy Control Subjects

	Total n(%)	Control n(%)	Hypothyroidism n(%)	Odds Ratio (95% CI), P
Codominant Modal
A/A	21(13.3%)	14(15.4%)	7(10.4%)	1.871(0.662–5.288), 0.237
G/A	77(48.7%)	46(50.5%)	31(46.3%)	1.388(0.703–2.743),0.345
G/G	60(38.0%)	31(34.1%)	29(43.3%)	1
Total	158(100.0%)	91(100.0%)	67(100.0%)
Dominant Modal
A/A	21(23.9%)	14(26.9%)	7(19.4%)	1.53(0.546–4.267)0.420
*X/G	67(76.1%)	38(73.1%)	29(80.6%)	1
Total	88(100.0%)	52(100.0%)	36(100.0%)
Recessive Modal
A/X*	28(31.8%)	21(40.4%)	7(19.4%)	2.806(1.039–7.583)0.042
G/G	60(68.2%)	31(59.6%)	29(80.6%)	1
Total	88(100.0%)	52(100.0%)	36(100.0%)
Alleles
A	98(41.7%)	60(43.8%)	38(38.8%)	1.23(0.725–2.087)0.442
G	137(58.3%)	77(56.2%)	60(61.2%)	1
Total	235(100.0%)	137(100.0%)	98(100.0%)

Note: *Where X can be A or G.

Abbreviations: CI, confidence interval; P, P-value.