Figures & data
Table 1 Drug loading with two-factor central composite design
Figure 1 3D response surface plot showing the influence of the polymer ratio and stirring time on drug loading.
Figure 2 SEM images of (A) CNF aerogel and (B) DCNF aerogel.
Abbreviations: SEM, scanning electron microscopy; CNF, cellulose nanofiber; DCNF, drug-loaded CNF; WD, working distance; EHT, electron high tension.
Figure 3 TEM images of (A) CNF and (B) DCNF aerogels.
Abbreviations: TEM, transmission electron microscopy; CNF, cellulose nanofiber; DCNF, drug-loaded CNF.
Figure 4 Swelling indexes of CNF and DCNF aerogels at different time intervals in media with different pH values. Error bar represents the standard deviation (n=6).
Abbreviations: CNF, cellulose nanofiber; DCNF, drug-loaded CNF.
Figure 5 Mucoadhesive strength of (A) CNF aerogel and (B) DCNF aerogel.
Abbreviations: CNF, cellulose nanofiber; DCNF, drug-loaded CNF.
Figure 6 Tensile strength of (A) CNF aerogel and (B) DCNF aerogel.
Abbreviations: CNF, cellulose nanofiber; DCNF, drug-loaded CNF.
Figure 7 In vitro drug release in media with pH 1.2 and pH 7.4 at different time intervals.
Abbreviation: DCNF, drug-loaded cellulose nanofiber.
Figure 8 Study profiles of release kinetics.
Notes: (A) Zero order; (B) first order; (C) Korsmeyer–Peppas; (D) Higuchi.
Figure 9 HPLC chromatogram of bendamustine hydrochloride in rat plasma.
Abbreviation: HPLC, high-performance liquid chromatography.
Table 2 Pharmacokinetic parameter results
Figure 10 Drug concentrations in blood vs time. Error bar represents standard deviation (n=6).
Abbreviation: iv, intravenous.
