25 [OH] Vitamin D and Intact Parathyroid Hormone in Congolese Hemodialysis Patients: Evaluation of KDIGO Targets

Figures & data

Table 1 Sociodemographic Characteristics of Patients

Variables	Whole Group n=251	Men n=182	Women n=69	p
Age years old	56 ±14	57 ±14	53 ±14	0.053
Age < 40	37 [15]	24 [13]	13 [19]	0.435
40–59	103 [41]	74 [41]	29[42]
≥ 60	111 [44]	84 [46]	27 [39]
Financing of care	80 [32]	66 [36]	14[20]	0.010
Higher and universities studies	133 [53]	113 [62]	20[29]	< 0.001
Hypertension	157 [63]	115 [63]	42 [61]	0.422
Diabetes mellitus	78 [31]	56 [31]	22[32]	0.489
Tobacco	51 [20]	49 [27]	2[3]	< 0.001
Alcohol	118 [47]	102 [56]	16 [23]	< 0.001
Obstructive uropathy	5 [2]	3 [2]	2 [3]	0.420
BMI Thinness	25 [10]	13 [7]	12 [17]	0.094
Normal weight	144 [57]	109 [60]	35[51]
Overweight	60 [24]	45 [25]	15[21]
Obesity	22 [9]	15 [8]	7 [10]

Notes: Results expressed either as mean ± standard deviation or as absolute frequency (percentage).

Abbreviation: BMI: body mass index.

Table 2 Biological Characteristics and Dialysis Parameters of Patients

Variables	Whole Group n=251	Men n=182	Women n=69	p
Hb, g/dl	8.5 ±1,9	8.6 ± 2.0	8.4 ± 1.7	0.522
Anemia	237 [94]	173 [95]	64[93]	0.332
Hct, %	25.8 ± 6.2	26.2 ± 6.3	24.7 ± 6.0	0.144
WBC/mm^3	7753± 4353	7800 ±4513	7637 ±3972	0.824
WBC < 4000/mm^3	24 [10]	16 [9]	8 [12]	0.694
WBC 4000–10,000/mm^3	174 [69]	125 [69]	49 [71]
WBC > 10,000 /mm^3	53 [21]	41 [23]	12 [17]
Platelets < 1.5x10^3 /mm^3	229 ± 87	220 ± 84	247 ± 90	0.162
Total cholesterol ≥ 150 mg/dL	38 [15]	29[16]	9 [13]	0.362
LDLc ≥ 100 mg/dL	83 [33]	68 [37]	15 [22]	0.013
HDLc < 40 mg/dL [man], < 50 mg/dL [woman]	187[75]	140 [77]	47 [68]	0.104
TG ≥ 150 mg/dL	73 [29]	47 [26]	26[38]	0.047
HIV antibodies	6 [2]	4 [2]	2 [3]	0.529
HCV antibodies	11[4]	8 [4]	3 [4]	0.641
HbS antigen	6 [2]	4 [2]	2 [3]	0.529
Ionized calcium	0.98±0.38	0.97±0.31	0.99±0.52	0.801
Phosphatemia	2.57±1.79	2.58±1.85	2.56±1.63	0.950
25 [OH] D	22.6±15.1	21.1±14.5	26.6±16.5	0.017
iPTH	192±251	203±252	163±249	0.258
HD	178 [71]	131 [72]	47 [68]	0.325
HD + HDF	73 [29]	51 [28]	22 [32]
Bath Mg^++ 0.5	73 [29]	51 [28]	22 [32]	0.325
Bath, Mg^++ 1	178 [71]	131 [72]	47 [68]
Bath, Ca^++ 1.75	73 [29]	51 [28]	22 [32]	0.325
Bath, Ca^++ 1,5	178 [71]	131 [72]	47 [68]
Bath, Cl^− 107	73 [29]	51 [28]	22 [32]	0.325
Bath, Cl^− 91	178 [71]	131 [72]	47 [68]
Bath, Na^+ 138	73 [29]	51 [28]	22 [32]	0.325
Bath, Na^+ 140	178 [71]	131 [72]	47 [68]
Bath, bicarbonate 32	73 [29]	51 [28]	22 [32]	0.325
Bath, Bicarbonate 35	178 [71]	131 [72]	47 [68]
High permeability dialyzer	76 [29]	53 [29]	23 [33]	0.308
Low permeability dialyzer	175 [71]	129 [71]	46 [67]
≤ 1 session per week	63 [25]	42 [23]	20 [29]	0.589
2 sessions per week	23 [9]	18 [10]	5 [7]
≥ 3 sessions per week	165 [66]	122 [67]	44 [64]

Notes: Results expressed either as mean ± standard deviation or as absolute frequency [percentage].

Abbreviations: Hb, hemoglobin; HbS, hepatitis B surface; Hct, hematocrit; HD, hemodialysis; HDF, hemodiafiltration; WBC, white blood cells; LDL, low density lipoprotein; HDL, high density lipoprotein; TG, triglycerides; HIV, human immunodeficiency virus; HCV, hepatitis C virus; iPTH, intact parathyroid hormone; 25 [OH] D, 25 hydroxy vitamin D.

Table 3 Number of Patients Achieving 2017 KDIGO Targets and Vitamin D Status

	iPTH
	≤ 15 pg/mL	16–150 pg/mL	151–600 pg/mL	> 600 pg/mL
25 [OH] D, deficiency	11	53	48	7
Insufficiency	4	13	62	2
Normal value	6	30	13	2
Total	21	96	123	11

Abbreviation: 25 [OH] D, 25 hydroxy vitamin D.

Table 4 Factors Associated with Hypovitaminosis D in Chronic Hemodialysis Patients

	Univariate Analysis			Multivariate Analysis
	OR	CI 95%	p	aOR	CI 95%	P
Hyperphosphatemia vs no	2.0	1.0–3.3	0.043	2.0	1.0–5.0	0.053
Male vs female sex	2.8	1.4–5.2	0.002	2.7	1.4–5.2	0.004
Low permeability dialyzer vs high permeability	2.3	1.2–4.3	0.010	2.2	1.1–4.2	0,025
Anemia vs no	4.4	1.5–13.1	0.005	3.9	1.2–12.7	0.022
Obesity vs no	2.5	1.0–6.2	0.050	–	–	–
Bath, Ca++ 1.5 vs 1.75	2.2	1.2–4.2	0.013	–	–	–
Bath, bicarbonate 32 vs 35	0.5	0.2–0.9	0.013	–	–	–
HD vs HD + HDF	2.2	1.2–4.2	0.013	–	–	–

Data Sharing Statement

The database is available from the corresponding author on reasonable request.