Cycle control with an extended-regimen oral contraceptive combining levonorgestrel and ethinyl estradiol that includes continuous low-dose ethinyl estradiol instead of the traditional hormone-free interval

Figures & data

Figure 1 Percentage of women reporting the occurrence of scheduled bleeding (A) or spotting (B) during each extended-regimen 91-day cycle.

Note: Women receiving 91-day extended-regimen COC with 30 µg EE/150 µg LNG for 84 days and EE 10 µg for 7 days showed a 10% increase in the likelihood of reporting no scheduled bleeding (OR =1.102 [95% CI: 1.006–1.206]) and a 9% increase in the likelihood of reporting no scheduled spotting (OR =1.085 [95% CI: 1.005–1.170]) for each additional 91-day cycle completed.
Abbreviations: COC, combined oral contraception; EE, ethinyl estradiol; LNG, levonorgestrel.

Figure 2 Percentage of women reporting 0 to ≤6 days or >6 days of unscheduled bleeding during each extended-regimen 91-day cycle.

Note: Women receiving 91-day extended-regimen COC with 30 µg EE/150 µg LNG for 84 days and EE 10 µg for 7 days showed a 53% increase in the likelihood of reporting 0 to ≤6 days of unscheduled bleeding per 91-day cycle (OR =1.531 [95% CI: 1.393–1.683]).
Abbreviations: COC, combined oral contraception; EE, ethinyl estradiol; LNG, levonorgestrel.

Figure 3 Percentage of women reporting 0 to ≤6 days or >6 days of unscheduled spotting during each extended-regimen 91-day cycle.

Note: Women receiving 91-day extended-regimen COC with 30 µg EE/150 µg LNG for 84 days and EE 10 µg for 7 days showed a 31% increase in the odds of reporting 0 to ≤6 days of unscheduled spotting per 91-day cycle (OR =1.307 [95% CI: 1.205–1.418]).
Abbreviations: COC, combined oral contraception; EE, ethinyl estradiol; LNG, levonorgestrel.

Figure 4 Percentage of women reporting no unscheduled bleeding during each extended-regimen 91-day cycle by COC use history (A), smoker status (B), BMI (C), and age (D).

Note: *Chi-square test, P<0.05.
Abbreviations: COC, combined oral contraception; BMI, body mass index.