Current perspectives on fetal and neonatal alloimmune thrombocytopenia – increasing clinical concerns and new treatment opportunities

Figures & data

Figure 1 Pathophysiology of maternal HPA-1 alloimmunization.

Notes: In an HPA-1bb mother who is pregnant with an HPA-1ab fetus, fetal platelets/fetal platelet antigen may enter the maternal circulation and lead to the production of anti-HPA-1a antibodies in the mother. Copyright © 2003. The Norwegian Medical Association. Reproduced from Heier HE, Berge LN, Hervig T, et al. Immunisering i svangerskapet. [Immunization during pregnancy]. Tidsskr Nor Laegeforen. 2009;129(19):2016–2018.¹³⁷
Abbreviation: HPA, human platelet antigen.

Figure 2 Baseline characteristics of HPA-1-induced fetal and neonatal alloimmune thrombocytopenia.

Abbreviations: ICH, intracranial hemorrhage; FNAIT, fetal and neonatal alloimmune thrombocytopenia; HPA, human platelet antigen.

HeierHEBergeLNHervigTImmunisering i svangerskapet. [Immunization during pregnancy]Tidsskr Nor Laegeforen2009129192016201819823209

 PubMedGoogle Scholar