Association between COMT polymorphism, labor anxiety, and analgesia in pregnant women

Figures & data

Figure 1 A flowchart of this study.

Abbreviation: SAI, State Anxiety Inventory.

Table 1 COMT genotypes and allele frequencies among pregnant women (%)

COMT genotype			COMT allele mutation
GG	AA	GA	G	A
46.0%	20.3%	33.7%	67.2%	32.8%

Table 2 Comparison of general data of pregnant women among the groups

Group	n	Agea (years)	Weighta (kg)	Heighta (cm)	Dysmenorrheab (%)	Gestationalb age (weeks)	Fibroidb (%)
GG group	180	26.6±3.4	68.2±7.4	161.3±4.0	86 (47.8)	39.4±1.1	4 (2.2)
AA group	99	26.7±3.2	67.87±7.5	162.3±4.3	48 (48.4)	39.3±1.5	4 (4.0)
GA group	132	26.6±3.3	68.3±7.3	163.2±4.1	64 (48.5)	39.2±1.8	4 (3.0)

Notes: Data are presented as mean ± SD or n (%).

a One-way ANOVA;

b chi-squared test.

Table 3 Comparison of SAI score among the groups

Group	48 hours before	24 hours before	12 hours before	6 hours before	6 hours after	12 hours after	24 hours after	48 hours after
GG group	42±5	45±5	43±5	44±5	44±6	45±6	43±5	42±5
AA group	50±6*	51±5*	53±6*	52±6*	52±5*	53±4*	51±5*	49±5*
GA group	48±6*	50±5*	49±2*	50±4*	50±5*	52±6*	51±5*	50±6*

Note:

* Compared with the GG group, one-way ANOVA; a P-value <0.05 was assumed to indicate statistical significance.

Abbreviation: SAI, State Anxiety Inventory.

Table 4 Comparison of VAS scores among the genotype groups

Group	48 hours before	24 hours before	12 hours before	6 hours before	1 hour after	6 hours after	12 hours after
GG group	0.8±0.3	1.0±0.4	1.5±0.4	2.2±0.5	1.2±0.4	1.1±0.5	0.9±0.3
AA group	1.2±0.3*	1.4±0.5*	2.3±0.5*	3.5±0.6*	2.2±0.5*	2.0±0.5*	1.8±0.4*
GA group	1.3±0.4*	1.5±0.6*	2.6±0.5*	3.3±0.5*	2.3±0.5*	2.2±0.6*	2.0±0.5*

Note:

* Compared with the GG group, one-way ANOVA; a P-value <0.05 was assumed to denote statistical significance.

Table 5 Comparison of Ramsay sedation scores among the genotype groups

Group	48 hours before	24 hours before	12 hours before	6 hours before	1 hour after	6 hours after	12 hours after
GG group	2.4±0.4	2.5±0.4	2.4±0.3	2.4±0.4	2.5±0.6	2.4±0.5	2.5±0.4
AA group	2.2±0.3*	2.1±0.5*	2.0±0.4*	1.6±0.3*	1.8±0.4*	1.9±0.6*	2.1±0.5*
GA group	2.1±0.5*	2.0±0.5*	2.1±0.4*	1.8±0.3*	1.8±0.4*	2.0±0.5*	2.1±0.4*

Note:

* Compared with the GG group, one-way ANOVA; a P-value <0.05 was assumed to denote statistical significance.

Table 6 Comparison of epinephrine levels among the genotype groups (ng/mL)

Group	48 hours before	24 hours before	12 hours before	6 hours before	1 hour after	6 hours after	12 hours after
GG group	0.8±0.1	1.1±0.2	1.1±0.2	1.3±0.1	1.2±0.2	1.3±0.2	1.2±0.2
AA group	1.5±0.4*	1.6±0.4*	1.6±0.3*	1.8±0.2*	1.9±0.3*	1.8±0.2*	1.8±0.3*
GA group	1.4±0.5*	1.5±0.3*	1.5±0.3*	1.6±0.2*	1.6±0.2*	1.7±0.3*	1.6±0.3*

Note:

* Compared with the GG group, one-way ANOVA; a P-value <0.05 was assumed to indicate statistical significance.

Table 7 Comparison of norepinephrine levels among the genotype groups (ng/mL)

Group	48 hours before	24 hours before	12 hours before	6 hours before	1 hour after	6 hours after	12 hours after
GG group	0.33±0.02	0.35±0.04	0.38±0.02	0.39±0.03	0.41±0.02	0.37±0.04	0.35±0.02
AA group	0.46±0.05*	0.48±0.03*	0.52±0.04*	0.56±0.03*	0.58±0.04*	0.53±0.04*	0.55±0.04*
GA group	0.45±0.03*	0.48±0.02*	0.51±0.05*	0.55±0.03*	0.55±0.03*	0.55±0.03*	0.55±0.03*

Note:

* Compared with the GG group, one-way ANOVA; a P-value <0.05 was assumed to denote statistical significance.