Variants in the Upstream Region of the Insulin Receptor Substrate-1 Gene Is Associated with Major Depressive Disorder in the Han Chinese Population

Figures & data

Table 1 Results of the Pairwise Haplotype Test Between MDD and Control Groups

Haplotype^a	Frequency (%)		P^b	Odds Ratio[95% CI]
	Cases	Controls
rs13411764- rs3820926
A-G	52.0	55.3	0.11	0.87[0.73~1.03]
A-T	23.6	24.6	0.58	0.94[0.77~1.16]
G-T*	22.7	18.1	0.01	1.33[1.07~1.65]
rs10203363-13411764
C-A	58.0	62.6	0.03	0.83[0.67~0.98]
T-A	17.5	17.2	0.83	1.03[0.82~1.29]
T-G	22.1	18.0	0.02	1.30[1.05~1.61]

Notes: ^aHaplotypes with frequency <5% are ignored in the analysis. ^bThe P-values for single haplotype test, d.f.=1, not corrected for multiple tests. Bold values were statistically significant. *p<0.05.

Abbreviation: CI, confidence interval.

Figure 1 Pairwise linkage disequilibrium(LD) among the 4 single nucleotide polymorphisms (rs10203363, rs13411714, rs1522813, and rs3820926). LDs are observed between rs10203363 and rs13411714 (D’0.83 [red box], r² 0.33), and between rs13411714 and rs3820926 (D’0.84 [red box], r² 0.25).

Table 2 Association Between Selected SNPs and a Family History of Mental Illness

SNP ID	Genotype	Family History N(%)		P^a	P^b	χ^2	Odds Ratio [95% CI]
		(-)	(+)
rs13411764*	AA	146(94.8)	29(78.4)	<0.01	0.02	8.46	5.03 [1.75~14.50]
	AG/GG	8(5.2)	8(21.6)
rs10203363	CC	63(41.7)	7(20.0)	0.02	0.10	5.71	2.87 [1.18~6.97]
	CT/TT	88(58.3)	28(80.0)
rs3820926	GG	43(27.9)	7(18.9)	0.26		1.25	1.66 [0.68~4.06]
	GT/TT	111(72.1)	30(81.1)
rs1522813	GG	66(42.9)	11(31.4)	0.21		1.54	1.64 [0.75~3.58]
	AA/AG	88(57.1)	24(68.6)

Notes: ^aRaw P-values. ^bP-values after Bonferroni correction; -, presence; +, absence. Bold values were statistically significant. *p<0.05

Abbreviations: SNP, single nucleotide polymorphism; CI, confidence interval.

Table 3 Association Between the rs13411764-rs3820926 G-T Haplotype and a Family History of Mental Illness

Haplotype	Family History N(%)		P	χ^2	Odds Ratio[95% CI]
	(-)	(+)
A-G/A-T	89(57.1)	11(29.7)	0.003	8.942	3.14[1.45~6.80]
G-T	67(42.9)	26(70.3)

Notes: -, presence; +, absence.

Abbreviation: CI, confidence interval.