Treatment Continuation of Asenapine or Olanzapine in Japanese Schizophrenia Patients: A Propensity Score Matched Study

Figures & data

Table 1 Patient Characteristics

	All Cases Before Propensity Score Matching			Matched Cases After Propensity Score Matching
	Asenapine	Olanzapine	SMD	Asenapine	Olanzpine	SMD
	(N = 46)	(N = 49)		(N = 33)	(N = 33)
Age (year), mean ± SD	42.0 ± 15.3	43.8 ± 15.6	0.12	41.8 ± 15.9	41.4 ± 15.3	0.025
Male sex (%)	18 (39.1)	18 (36.7)	0.049	13 (39.4)	14 (42.4)	0.062
Chlorpromazine equivalent (mg), mean ± SD	452.9 ± 324.4	500.9 ± 396.7	0.13	453.5 ± 285.1	437.1 ± 342.5	0.052
Diazepam equivalent (mg), mean ± SD	7.7 ± 10.8	4.6 ± 6.6	0.35	4.8 ± 5.8	4.9 ± 7.5	0.024
History of clozapine use (%)	3 (6.5)	0 (0.0)	0.37	0 (0.0)	0 (0.0)	<0.001
History of modified Electro Convulsive Therapy (%)	9 (19.6)	13 (26.5)	0.17	5 (15.2)	6 (18.2)	0.081

Abbreviations: SD, standard deviation; SMD, standardized mean difference.

Figure 1 Continuation rate of treatment calculated by the Kaplan–Meier method before propensity score matching.

Figure 2 Continuation rate of treatment calculated by the Kaplan–Meier method after propensity score matching.

Table 2 Reason for Discontinuation of Each Antipsychotic

Rseason for Discontinuation, n (%)	Asenapine (n = 46)						Olanzapine (n = 49)
	Total		<1 Month		1–6 Month		Total		<1 Month		1–6 Month
Lack of efficacy	6	(13.0)	2	(4.3)	4	(8.7)	5	(10.2)	2	(4.1)	3	(6.1)
Insomnia	5	(10.9)	1	(2.2)	4	(8.7)	1	(2.0)	1	(2.0)	0	(0.0)
Akathisia	4	(8.7)	4	(8.7)	0	(0.0)	1	(2.0)	1	(2.0)	0	(0.0)
Bitter taste	3	(6.5)	3	(6.5)	0	(0.0)	0	(0.0)	0	(0.0)	0	(0.0)
Burden of dosing method	3	(6.5)	2	(4.3)	1	(2.2)	0	(0.0)	0	(0.0)	0	(0.0)
Fatigue	2	(4.3)	2	(4.3)	0	(0.0)	1	(2.0)	0	(0.0)	1	(2.0)
Dizziness	2	(4.3)	2	(4.3)	0	(0.0)	3	(6.1)	3	(6.1)	0	(0.0)
Somnolence	2	(4.3)	2	(4.3)	0	(0.0)	0	(0.0)	0	(0.0)	0	(0.0)
Dyspnea	2	(4.3)	2	(4.3)	0	(0.0)	0	(0.0)	0	(0.0)	0	(0.0)
Dysarthria	2	(4.3)	1	(2.2)	1	(2.2)	0	(0.0)	0	(0.0)	0	(0.0)
Weight gain	1	(2.2)	1	(2.2)	0	(0.0)	7	(14.3)	3	(6.1)	4	(8.2)
Neuroleptic malignant syndrome	1	(2.2)	1	(2.2)	0	(0.0)	0	(0.0)	0	(0.0)	0	(0.0)
Dystonia	1	(2.2)	1	(2.2)	0	(0.0)	0	(0.0)	0	(0.0)	0	(0.0)
Sialorrhea	1	(2.2)	0	(0.0)	1	(2.2)	0	(0.0)	0	(0.0)	0	(0.0)
Convulsion	1	(2.2)	1	(2.2)	0	(0.0)	0	(0.0)	0	(0.0)	0	(0.0)
Weakness	1	(2.2)	1	(2.2)	0	(0.0)	0	(0.0)	0	(0.0)	0	(0.0)
Increased appetite	1	(2.2)	1	(2.2)	0	(0.0)	0	(0.0)	0	(0.0)	0	(0.0)
Photophobia	1	(2.2)	1	(2.2)	0	(0.0)	0	(0.0)	0	(0.0)	0	(0.0)
Dry mouth	0	(0.0)	0	(0.0)	0	(0.0)	2	(4.1)	1	(2.0)	1	(2.0)
Constipation	0	(0.0)	0	(0.0)	0	(0.0)	1	(2.0)	0	(0.0)	0	(0.0)